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    Sequence ME & Long Covid now open for fundraising

    Thank you!
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    Sequence ME & Long Covid now open for fundraising

    That's me. I'm delighted it's already over £1000 in less than 24 hours.
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    Evidence of White Matter Neuroinflammation in [ME/CFS]: A Diffusion-Based Neuroinflammation Imaging Study 2026 Yu et al

    When you say flat, do you mean completely flat, head not propped up at all?
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    USA: Mount Sinai PACS clinic and Dr David Putrino

    I will bet £10 that these "early" results will also be described as "promising".
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    Mitochondrial transfer from glia to neurons protects against peripheral neuropathy, 2026, Xu et al

    Yes, absolutely - especially as these particular nerves aren't only involved in pain sensation (which these researchers are focusing on) but also, if I understand rightly, in regulating heart rate and blood pressure, respiration, digestion, and more.
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    Mitochondrial transfer from glia to neurons protects against peripheral neuropathy, 2026, Xu et al

    I was getting interested in this until I read "In some cases, the relief lasted up to 48 hours." Oh well. Still:
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    Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID, 2025, Ribeiro et al.

    I had this microneurography testing at KCH recently and the results are similar to what they found in this study ("ongoing spontaneous activity" and "extreme slowing of conduction velocities"). Without going into detail, partly for confidentiality and partly because I can't remember all the...
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    Uta Frith: why I no longer think autism is a spectrum

    I noticed this blog post responding to Frith and had to smile at the following: There might be one other...
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    Uta Frith: why I no longer think autism is a spectrum

    Yes, I'll need a bit of time to put it into words but I'll come back to this. The simplest way I can put it is that as a healthy autistic person I was energised by the things I enjoyed doing, physically or mentally, whereas with this illness any expenditure of energy knocks me out, whether it's...
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    Uta Frith: why I no longer think autism is a spectrum

    Frith says "I think it’s useful to make clear distinctions between the different types of children who have been diagnosed as autistic", but when I think of the autistic children I know in real life, many of them don't fit into any of her 'clear' categories. There are those who are...
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    Medical assistance in dying (MAID), and how it relates to ME/CFS

    I wouldn't take anything from NY Post at face value.
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    Increased incidence of mild cognitive impairment in long COVID patients, 2026, Frontera et al.

    Useful that they had pre-2020 data on subjects so they could compare pre and post illness cognitive performance. Also that they seem to have made a real effort to check covid-negative status for controls. For anyone else looking for the raw numbers: 260 patients, median age of 70, of whom 113...
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    The Setpoint Trap: A New Way to Think About ME/CFS (Desmolysium.com)

    https://www.s4me.info/tags/metformin/ Probably some food for thought here, though of course no definite answers!
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    The Setpoint Trap: A New Way to Think About ME/CFS (Desmolysium.com)

    It's also studying nurses early in the pandemic, who as a group were under unusual stress and exposed to unusual health risks, so not really generalisable to broader populations.
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    The Setpoint Trap: A New Way to Think About ME/CFS (Desmolysium.com)

    Also I can kind of see why doctors might think they're seeing 'anxiety' when a patient is breathing erratically or seems to be distracted or finding it hard to organise their words, when actually it's physical distress and/or cognitive impairment. Or they think they're seeing 'depression' when...
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    UK: Disability benefits (UC, ESA and PIP) - news and updates 2026

    I'm not, but thanks! Basically it's about how much record-keeping is involved. I won't be doing it myself but I need to brief the person who probably will.
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