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    Recovery from chronic fatigue syndrome: a reflexive thematic analysis of experiences of people before, during and after treatment, 2025, Chalder+

    "You see, it's not that CBT isn't helpful, it's just that the poor dears don't realise they've been helped."
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    Review Evaluating Pacing Therapy versus GET for improving fatigue, pain, and quality of life in adults with ME/CFS, 2025, Cooper

    Just noticing this is now dated October 2025, don't know if there have been any significant amendments. https://www.sciencedirect.com/science/article/pii/S1360859225002025
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    Effect of subcutaneous lidocaine–hydroxypropyl-β-cyclodextrin (HP-β-CD) on quality of life in patients with post-COVID condition…, 2025, Oostwouder+

    Single-digit improvements in subjective symptom scores over 36 weeks, from low 30s to mid or high 30s, still well below the score of 50 which suggests poor health on the SF12. That's not making me want to queue up for daily subcutaneous injections. Nope. Also nope.
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    Relationship between body mass index, gray matter volume and peripheral inflammation in patients with post-COVID condition, 2025, Claaß et al.

    I've found that one way to get a quick sense of papers like this is to do a keyword search for terms such as 'however'.
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    UK Government Delivery Plan for ME/CFS, published 22nd July 2025

    The title 'Prioritise Research Over Training' lends itself to an acronym, which apparently one has to have these days. Prioritise Research Over Training and End Counterproductive Therapies for ME - PROTECT-ME?
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    UK Government Delivery Plan for ME/CFS, published 22nd July 2025

    There's a rapid response to that BMJ piece from Edoardo Cervoni, Director, Locumdoctor4u Ltd. Southport https://www.bmj.com/content/390/bmj.r1585/rr Excerpt: He should join S4ME (unless he already has, under a pseudonym!)
  7. E

    The ruling out of other conditions: do you think you've had adequate ruling out of other conditions?

    The King wouldn't be satisfied with standard care, that's for sure. https://www.independent.co.uk/life-style/royal-family/king-charles-homeopathy-head-medical-household-b2461795.html https://www.facultyofhomeopathy.org/pages/Patron
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    A Mixed-Methods Evaluation of a [Post-COVID] and Recovery Intervention Delivered in a Football Club Community Trust, 2025, Rimmer et al.

    There was that tennis programme. https://www.s4me.info/threads/uk-nhs-feel-good-tennis-for-long-covid.38700/
  9. E

    Scientific research journals and publishers

    https://neuromatch.social/@neuralreckoning/115621920496307977 Post includes horrendous AI slop image from the first publication referred to.
  10. E

    Construct validity of self-reported and interview-guided administration methods of the Danish version of the [PCFS], 2025, Sørensen+

    Another example of the assumption early in the pandemic that the sequelae of Covid-19 would mainly involve respiratory complications. It's good that the failings of this approach are being recognised.
  11. E

    Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19, 2025, Seo et al.

    Is the stuff about iron accumulation potentially interesting? Thinking of a few other studies where iron/ferritin has come up.
  12. E

    Preprint A region-specific brain dysfunction underlies cognitive impairment in long COVID brain fog, 2025, Yang et al

    Baseline and post-stimulation box plots for the real and sham TUS (20 people each) don't look like they've found anything especially gamechanging.
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    Effectiveness of Five-Element Regulatory Therapy for post-COVID syndrome: a retrospective cohort study, 2025, Ding et al.

    and the treatment lasted two weeks. So one thing they've confirmed is that lots of post-acute Covid symptoms clear up within a short time. The Five Elements are supposedly the stages of disease, and the patients in the treatment group received different herbal medicines according to which stage...
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    Network structure underpinning (dys)homeostasis in chronic fatigue syndrome; Preliminary findings. Clark, Newton et al. 2019

    The authors note the limitations of small sample sizes and the lack of a control group for the 'combined network'. They haven't spotted another limitation, which is that they only tested people with CFS (Fukuda) against healthy controls, no other disease condition.
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    Trial Report Resistance Exercise Therapy for Long COVID: a Randomized, Controlled Trial 2025 Berry et al.

    So the intervention group had about a 50% greater likelihood of having an 'indication of ME/CFS diagnosis' than the standard care group after 3 months?
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