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I think Jonathan Kipnis is making important discoveries about the role of different types of T cells in the meninges https://pubmed.ncbi.nlm.nih.gov/40324376/

As great as this team is for doing an in-depth study, the focus on cortisol will only hurt us as docs will make one measurement at the time of day of your appointment and it will likely be in the normal range for most people with ME or LC. The authors put far too much emphasis on the cortisol...

Did anyone who heard or read this transcript get an idea of what percentage of these newly diagnosed (<5 years) pwme were found to have an active infectious agent or an autoimmune disease? Maybe this is what people are saying above - that we don't know what percentage. I go to a doc in an...

Thanks @rvallee posting this important point. I agree with @butter. that our current understanding about human biology is less than 5%. After doing post-doctoral training in mammalian biology, then devoting most of my waking life to understanding biology as a professor, I came home so many days...

I really like what you are saying! Selin is onto something here. Yes she is a long-time T cell expert, and she's understated. Those are often the ppl who do important work.

The media folks also thought it would be helpful to put a old unplugged microscope plus 3 volumetric flasks on the desk in front of the speakers to give credibility. Same setup/desk used for the Dr Komaroff talk. Someone’s trying anyway.

With all the work that people did to send in questions and to @Andy for setting up this video discussion with Dr. V, a huge thanks to everyone on the forum - you helped save my life. 23 years with this disease, the last 5 have really not been living, certainly not contributing, but this...

Yes, this is how most scientists are trained (in contrast to MD's): that if you know the underlying biology of a particular cell type or tissue type, then you are better equipped to figure out what is amiss during disease. Most of us would like to see a smaller defense budget and bigger...

hmm....that is surprising since we all know that the amount of funding for this disease per patient, is much less than MS, HIV-AIDS, etc. In the states, it's the least funded disease of any known. If we are talking about "fundamental" research mechanisms that need more funding, do you (or Dr. V)...

Oh, very cool Andy. Stuck in my foggy brain was the vague idea that chronic diseases other than ME have mitochrondrial dysfunction in affected cell types. Did not realize that there exists "microvesicle-embedded mitochondria" This is from this Circ. Research article you posted above: "What Is...

Nice find Andy. Not sure if you know that Helen Blau is among the top muscle biologists in the world. This work is on muscle stem cells (previously known as satellite cells) in rodents. These stem cells are usually quiescent in adult muscle because muscle fibers are post-mitotic (fully...

I love this reply. And the statistics issue is consistent with my experience using multiple test correction. Bonferroni is overly strict, and one loses good (true) biological data when it is used.