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  1. Flying Dutchman

    Chapter 29 - Clinical neurophysiology of postural tachycardia syndrome, 2019, Sandroni et al

    Both authors are from the Mayo Clinic, so it's no surprise there is a psych attribution, and no surprise they appear to conflate CF with ME/CFS.
  2. Flying Dutchman

    Who is Simon Wessely?

    Can anyone help me track down an old Wessely interview... On 5 March 2010, BMJ uploaded an audio recording of an interview with Simon Wessely. BMJ's website long-ago deactivated the link to this interview. The interview contained this quote from SW: "We’re not going to go doing more and more...
  3. Flying Dutchman

    When a Placebo Is Not a Placebo: Problems and Solutions to the Gold Standard in Psychotherapy Research (2018) Blease et al.

    The article explains: "In every randomized controlled trial (RCT) the placebo should ideally be “bespoke” – tailored to mimic an intervention under investigation without consisting of any it's hypothesized characteristic constituents. While fulfilling this goal is enormously challenging, in drug...
  4. Flying Dutchman

    Guided graded exercise self-help for chronic fatigue syndrome: Patient experiences and perceptions, 2018, Cheshire et al

    It's not a student project: The first author, Anna Cheshire PhD, is an experienced researcher, having obtained her PhD >10yrs ago; Damien Ridge PhD is a full professor; Lucy Clark PhD has been a researcher for 20yrs; And the senior author is our slightly involuntarily retired friend, Peter...
  5. Flying Dutchman

    HIV-infected people are living for years, but age-related diseases set in early

    According to comments I've heard from Prof Sharon Lewin, a well known HIV researcher and the Director of a very large infectious diseases & immunology research institute (the Doherty Institute), the prognosis for HIV patients depends on their treatment history. Patients who start treatment...
  6. Flying Dutchman

    KPAX002 as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a prospective, randomized trial, 2018, Montoya et al

    KPAX is a bog-standard stimulant, Ritalin, mixed with some (presumably useless) over-the-counter supplements. Adding these "herbs & spices" allows them to claim the combo is a proprietary medicine. That is, KPAX can be patented, whereas the active ingredient (Ritalin) is out of patent. The...
  7. Flying Dutchman

    Our chronic fatigue syndrome/encephalomyelitis service is nice (?!), but is it patient friendly? experience of going beyond audit

    This was published in the Archives of Disease in Childhood, which is the official journal of the Royal College of Paediatrics and Child Health. This paper is an abstract presented at the RCPCH's Annual Conference, held in Glasgow, 13-15 March 2018. One thing that stands out is that the...
  8. Flying Dutchman

    David Tuller - Trial By Error: The Australian Situation

    The following is from the first Q&A - part of a reply by Penelope McMillan: "PACE has had a significant influence in Australia, through PACE materials included in the Royal Australian College of GPs’ website. Approaches by patients and GPs to have the materials removed from the website have...
  9. Flying Dutchman

    How to challenge Pervasive Refusal Syndrome

    Two observation about the Crawley article in the original post: 1. She extrapolates conclusions about the features of PRS on the basis of a tiny sample size. Her total sample: 7 cases of PRS. For some of the features of PRS about which she draws conclusions, she has data for just 3 patients...
  10. Flying Dutchman

    Correspondence from the DWP for 2004

    The 4th file (https://www.s4me.info/attachments/4671-14-09-2004-lynch-rose-to-ma-r-pdf.2049/) contains two emails. In the first (at the bottom of the page) Aylward writes to an MRC employee about how the MRC should invoice the DWP for payments relating to PACE. In that email, Aykward also...
  11. Flying Dutchman

    Zaher Nahle leaves Solve Me/cfs

    His qualifications were obviously out of whack with his SCMI job. It's hard to imagine many ppl with a CV like his being satisfied with a job like this (tiny organisation; unfashionable cause; no break-thru progress; comparatively modest pay) unless they really believed in the cause &/or the...
  12. Flying Dutchman

    The Inside Story Of How An Ivy League Food Scientist Turned Shoddy Data Into Viral Studies (Brian Wansink, Cornell)

    This is such an elegant story - a beautifully perfect train-wreck, so to speak. The Cornell prof in question got caught out by blogging about how to fish for relationships in data sets. He'd had a 30-yr academic career, and apparently had no idea that his normal research methodology (p-hacking)...
  13. Flying Dutchman

    Psychological Stress and Mitochondria: A Systematic Review Picard, Martin PhD; McEwen, Bruce S. PhD

    The senior author of the psycho-mito paper is a famous neuropsychiatry / neuroendocrinology researcher, Bruce McEwen. He is one of the fathers of modern psych theories of stress, and he coined the term "allostatic load". He is a very senior figure - he holds a named chair at Rockefeller Uni...
  14. Flying Dutchman

    Public "Integrative Personal Omics Profiles during Periods of Weight Gain and Loss", 2018, Synder et al

    [WARNING - OT post] Thanks Woolie, I switched avatar from a painting of Prince Henry Frederick to a memento mori pic of my dog. Henry was Charles II's older brother, and heir to James I & IV. He was highly capable, and promised a bright future for england. Instead, disease cut him down, young...
  15. Flying Dutchman

    Public "Integrative Personal Omics Profiles during Periods of Weight Gain and Loss", 2018, Synder et al

    The senior author of this paper is Michael Synder. He's Chair of the Genetics Dept at Stanford, and an absolute guru researcher. He is a world leader in the push to personalised medicine. He was a post-doc under Ron Davis, and Davis has more recently recruited him to research ME.
  16. Flying Dutchman

    3 Dec 2017 | Interview with Nancy Klimas on 'Unrest'

    Sadly, that's an understatement - it was not 10 or even 20 years ago; Nancy Klimas did that work approx 29 years back.
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