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Yes, this was my impression as well after looking at the table of raw results. The difference in IGVH3-23/30 is rather small, and in the human body most significant interactions are first-order, though not always linear, so the use of a second-order transform does not easily have "physical"...

Im going to try to explain what this study found. First, we need to be familiar with the structure of antibody. An antibody is an immunoglobulin (Ig) that can come in several classes (G, A, M, D and E). This is the prototypical antibody: Notice the red part. This is called the heavy chain...

This is great. I would love more commentary on the CNS pathology and excess glutamatergic tone (think Jay Goldstein) but it’s great nontheless, as much for biomed advances as for PR.

Wait wut, pyridostigmine, a cholinesterase inhibitor, works as a cholinergic, not an anticholinergic.

Bump. I was under the impression it was only classified as mental health, so this may be a positive change

Probiotics took me from an 8 to a 4-5 activity scale. On the other hand, they have been very helpful to a lot of people. I would suggest caution.

Yes, and my urine usually smells sweet. This only happens when I'm in a crash.

In the study they talk about hypoacetylation and of upregulation of HDAC enzymes, as well ass acetate deficiency. Also, if hypoxanthine serves as a proxy for ATP breakdown, PEM is a hypermetabolic state when compared with resting ME/CFS state.

SS-31 is still early in the pipeline, so not many human studies. Here is a phase II one for renal artery stentosis. https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.117.005487

SS-31 protects and restores cardiolipin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976620/

Slow breathing makes sense. Gargling also since it stimulates the vagal reflex. But ice water? I thought sudden cold activates the Sympathetic arm of the ANS. Maybe our ANS is so messed up anything that shakes it up works.

Wow, how much synchronicity. I just bought a polar H7 to track HRV in the Elite HRV. The 1st picture is of a meditation session, the second one is of me having a walk with pseudoephedrine and Mestinon (for alpha 1 stimulation) Sorry if you can't see the images well. I use redshift at night to...

Plz let it be because of good research

@Hip You appear to be "shadowbanned", a fate usually reserved for people Twitter deems are wrongthinkers. Edit: it seems you are not shadowbanned https://shadowban.eu/Hip_III

Palmitoylethanolamine (PEA), cannabidiol (CBD) and benfothiamine are neuropathy treatments with established research. Mercury can cause neuropathy, and is only weakly chelated by ALA, causing a redistribution rather that elimination which is known to increase symptoms.

The "something in the blood" news is very encouraging. Mostly because it has the potential to be a biomarker. No more BPS crap, but instead accurate animal models.

This is orwellian. How can you forbid patients to talk about something that is a primary outcome metric. It's like forbidding Hep. C patients from saying "liver" during a clinical trial. Or to forbid CVD patients from using the word "palpitations".

It's a great paper, if a little convoluted, but very up to date. They place emphasis on pem as a necessary part of study inclusion, which is great. The two strong points imho are the correlation of miRNA to immune dysregulation, and the conexion of tgf, il10 and cxcl8 with a hypoinmune state...

@Woolie this may be of interest: https://www.ncbi.nlm.nih.gov/m/pubmed/18325031/ Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappaB p65-associated histone acetyltransferase activity. So TNF, IL-8 and NF-kB.exactly...