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  1. Medfeb
    Post

    News From Jarred Younger / Neuroinflammation, Pain, and Fatigue Laboratory at UAB, From Aug 2020

    Thanks for highlighting that! ETA - If he is requiring PEM in all patients, he will hopefully update the info in clinicaltrials.gov. On the other...
    Post by: Medfeb, Apr 16, 2024 at 2:14 AM in forum: ME/CFS research news
  2. Medfeb
    Post

    News From Jarred Younger / Neuroinflammation, Pain, and Fatigue Laboratory at UAB, From Aug 2020

    Bolding added I believe these are two of Dr. Younger's three studies as listed in ClinicalTrials.Gov 1. Assessment of Neuroinflammation in...
    Post by: Medfeb, Apr 16, 2024 at 1:47 AM in forum: ME/CFS research news
  3. Medfeb
    Post

    Post-Exertional Malaise - a discussion including defining and measuring PEM

    So here's where I'm confused... @Ravn above noted: And the point of Workwell's Timeline slide is that pwME can learn early signs of...
    Post by: Medfeb, Apr 1, 2024 in forum: Post-Exertional malaise and fatigue
  4. Medfeb
    Post

    Post-Exertional Malaise - a discussion including defining and measuring PEM

    Thanks, @Trish. That's surprisingly good.
    Post by: Medfeb, Mar 30, 2024 in forum: Post-Exertional malaise and fatigue
  5. Medfeb
    Post

    Post-Exertional Malaise - a discussion including defining and measuring PEM

    Thanks for that and good to remember that OI can be playing an overlapping role. I don't know if this person would describe head pressure like...
    Post by: Medfeb, Mar 30, 2024 in forum: Post-Exertional malaise and fatigue
  6. Medfeb
    Post

    Post-Exertional Malaise - a discussion including defining and measuring PEM

    Another question to clarify - is there a standard definition for exercise intolerance? I ask because it seems that some LC clinical guidance and...
    Post by: Medfeb, Mar 30, 2024 in forum: Post-Exertional malaise and fatigue
  7. Medfeb
    Post

    Post-Exertional Malaise - a discussion including defining and measuring PEM

    Great discussion in this thread, especially separating out mechanisms from symptoms and change in function Just to clarify - How do you define...
    Post by: Medfeb, Mar 29, 2024 in forum: Post-Exertional malaise and fatigue
  8. Medfeb
    Post

    Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome, 2024, Walitt et al

    I think this is an important point. Reviewer #4, (appears to be Tony Komaroff, see p 6), questioned how they could have found no cognitive issues...
    Post by: Medfeb, Mar 17, 2024 in forum: ME/CFS research
  9. Medfeb
    Post

    Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    Not sure if this goes here or in the other thread. The paper noted: But this thread describes the high rate of failure of pwME on the EEfRT...
    Post by: Medfeb, Mar 14, 2024 in forum: ME/CFS research
  10. Medfeb
    Post

    Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome, 2024, Walitt et al

    I believe their point is that the selected participants did not reflect the spectrum of severity of ME. If I remember correctly, the average...
    Post by: Medfeb, Mar 10, 2024 in forum: ME/CFS research
  11. Medfeb
    Post

    CDC Multi-site Study: Heterogeneity in ME/CFS Illness Measures Not Explained by Clinical Practice, 2024, Unger et al

    This is just an additional paper from CDC's multi-site "MCAM" study, initiated in 2011. It's typical of CDC to dribble out papers from their...
    Post by: Medfeb, Mar 5, 2024 in forum: ME/CFS research
  12. Medfeb
    Post

    Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome, 2024, Walitt et al

    Of course. I was not saying there weren't. But redefining PEM as "feelings of discomfort" and then virtually ignoring PEM is a pretty big problem...
    Post by: Medfeb, Feb 22, 2024 in forum: ME/CFS research
  13. Medfeb
    Post

    Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome, 2024, Walitt et al

    The question of whether PEM was present or not is a nuanced one. They note the cases were adjudicated by experts and the supplemental data said...
    Post by: Medfeb, Feb 22, 2024 in forum: ME/CFS research
  14. Medfeb
    Post

    Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome, 2024, Walitt et al

    In the Discussion, they say: "Moreover, testing of effort preference and the participants’ own words are consistent with this finding [on central...
    Post by: Medfeb, Feb 22, 2024 in forum: ME/CFS research
  15. Medfeb
    Post

    Medications for Immune Deficiency: Intravenous immunoglobulin, Inosine pranobex, Hydroxychloroquine

    Immunoglobulin can be prescribed to people with common variable immune deficiency (CVID), which is diagnosed by specific biomarkers. This can...
    Post by: Medfeb, Jan 29, 2024 in forum: Drug and supplement treatments
  16. Medfeb
    Post

    Preprint Assessing Functional Capacity in ME/CFS: A Patient Informed Questionnaire, 2023, Sommerfelt et al

    This looks very useful. One question - I tried using this to score a severely ill patient I know and wasn't sure how to address the cumulative...
    Post by: Medfeb, Jan 14, 2024 in forum: ME/CFS research
  17. Medfeb
    Post

    Muscle abnormalities worsen after post-exertional malaise in long COVID, 2023/4, Wüst, van Vugt, Appelman et al

    I've been collating a list of ME/CFS provocation studies and there aren't many studies with cognitive challenges. Here's one evaluating autonomic...
    Post by: Medfeb, Jan 14, 2024 in forum: Long Covid research
  18. Medfeb
    Post

    Muscle abnormalities worsen after post-exertional malaise in long COVID, 2023/4, Wüst, van Vugt, Appelman et al

    In case it's helpful In case it's helpful, here's a transcript of Dr. Griffin's discussion on the Appleman paper Edited to replace the link...
    Post by: Medfeb, Jan 14, 2024 in forum: Long Covid research
  19. Medfeb
    Post

    Muscle abnormalities worsen after post-exertional malaise in long COVID, 2023/4, Wüst, van Vugt, Appelman et al

    Excellent discussion of the article.
    Post by: Medfeb, Jan 14, 2024 in forum: Long Covid research
  20. Medfeb
    Post

    Post-Exertional Malaise - a discussion including defining and measuring PEM

    Yes, I am. Also the differences that group found between severely and moderately ill patients with both having mitochondrial impairments but only...
    Post by: Medfeb, Dec 25, 2023 in forum: Post-Exertional malaise and fatigue
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