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Yes and from my understanding Naviaux’s hypothesis includes the suggestion that any initiating trigger likely needs resolving for CD-R problem to end

But isn’t the point of this article hypothesising that the causal agent becomes the stuck on CD-R which is then activated by any stressor ( so there is no need for the originating agents to be present to make the new system vulnerable to worsening from ongoing stressors

Whatever the mechanism I guess its likely that clonazapem is working in the same way. If these drugs are down regulating the clonally expanded T cells as in the Mike Davis hypothesis is it reasonable to think this would lead to more ATP production/better nano needle response and how quickly...

Thanks everyone for your replies. Like many things in this illness it seems there are many possibilities to what could potentially contribute to the strengthening affect. Interesting that Ron Davis mentioned ATP production as I hadn't seen that link in research I have reviewed

I think it definately must be the gaba effects @James Morris-Lent I just wonder how it is resulting in increased strength. I guess it is plausible that by relaxing muscles they are working better for that period but I also wondered if a dampening of t-cells could somehow be involved...

I read where for Whitney Dafoe ativan increases his strength for a short period. I am also interested in this as clonazapem does the same for me. I am completely bed bound and have had periods of months at a time when I am too weak to talk at all. I can currently talk in short sentences but only...

My muscle biopsy revealed: Selective type II atrophy- this finding is consistent with inflammatory and malnutrition disorders, both of which seem possible processes in ME Moderately reduced Glycogen levels- I have been researching what might cause this and there seem so many possibilities...

I was just about to start taking clonazapem again because it is the only drug I have found helpful throughout my time with illness. In searching for a possible reason I discovered that GABA downregulates T cells which I thought was very interesting given the Mark Davis research into clonal T...

@mariovitali I have low levels of albumin, transferrin, and ceruloplasmin. I note that these are all synthesised in the liver. Do you think these findings are relevant to your hypothesis? Are they common findings? Also, while I rarely see it discussed my me/cfs doctor who has been working...

I had ‘moderately reduced glycogen levels’ on my muscle biopsy even though I eat quite a bit of carbs. I am wondering whether this might be a common finding in ME in muscle tissue as well...

Hi @JaimeS . Thank you for your attendance of this conference... I am wondering if muscle weakness/atrophy is ever mentioned as part of dysautonomia?

Has anyone had muscle biopsy for muscle symptoms? If so what were findings...

Does anyone who gets the internal vibration or external shaking also have muscle weakness as major symptom?

@LightHurtsME I am the same regarding the external shaking... They can contribute to severe crashes for me I assume because body doesn’t have energy that they use... I find clonazapem can reduce the internal shaking when I have them.

Yes mine range from internal tremor where I can feel on inside but can’t see to severe external shaking episodes. I only get these in upper legs core and chest. Mine has changed over time where when I first got sick I would get visible shaking when I first tried to move legs when waking which...

Thank you @Mij I assume then that Ron Davis did these tests as part of severely ill study...Do you know if he has talked about results of this test anywhere?

Does anybody know if researchers have done any respiratory chain enzyme function analysis studies using muscle tissue in ME? The mitochondrial disease doctor I saw said that it is a way to diagnose genetic mito but I would think that respiratory chain enzyme dysfunction could be a secondary...

Hi @Gingergrrl Sorry for my slow response I haven't been on for a while...My doctor had health issues so its taken a while to get things moving again. So far I have increased Mestinon to 1 tablet 3 times a day with no side effects but no noticeable difference. I also got results for my Achr...

I think also all the severe patients in Stanford study had gene testing and none had known mito disease causing mutations. I think its also quite possible that what you get diagnosed with depends on the type of doctor you go to where from my understanding Mito doctors will diagnose mito disease...