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? Please elaborate.

Yep. Or the problem is there, just lurking in crappy testing protocols.

From the study: " ME/CFS also shares key neurologic features with PTLDS, particularly in its hallmark symptoms of profound fatigue, post-exertional malaise and cognitive impairment. ME/CFS is now strongly suspected to be an IACI, and research has identified possible underlying mechanisms that...

No shit. This has been a defining problem in LymeWorld for half a century. ETA: I'm curious to find out how they propose to resolve this dilemma what with the diagnostic logjam that's beset the community since the '80's. Patents pose serious hurdles.

I was in an ME/CFS study several years back where a lumbar puncture was required. I'd had a couple for other studies, so I wasn't overly concerned. But it took them well over an hour with that long needle embedded in my spine to withdraw enough fluid. They even manipulated the gurney they had me...

Judgement, reasoning, memory, word-finding, decision making - all, for me, can fail, abruptly, in noticeable fashion, just from a casual interaction or sudden emotion; or, can slowly erode during the course of a typical day merely from daily wear and tear. Very similar to what happens when...

Both muscle weakness and stamina for me can fluctuate. It's maddeningly unpredictable - and that's not even factoring in PEM. Neither is anywhere near to levels prior to ME/CFS, and both seem to be inexorably worsening, albeit gradually. But then, I am a senior getting older, so there's that...

I'm not sure that is the point. Regardless, if vector-borne diseases are at play in the pets of ME/CFS patients, and the symptoms approximate each other, that is a curiosity for some. That should in no way imply a causal association. I have ME/CFS and three tick-borne diseases. My small dog...

I imagine this is a function of poor wording, not 8 dogs at a given moment, but over time. Not atypical at all, at least not in the US. And yes, I can think of several diseases that, in pets, might appear similar symptom-wise to ME. Some would know. Increased signs of lethargy, a gait that is...

These were all U.S. cases. I don't think this necessarily implies a causal relationship of diseases between pet and pet owner. I think it suggests - at least in many cases - vector-borne diseases that the pets have that in fact do resemble ME/CFS. Anaplasmosis, Borrelia, Bartonella. The owner...

A chronicity rate of roughly 20% is strikingly familiar.

In 1999 I went camping. Was roughing it in the Northeast US woodlands for three days. This was a year before my symptoms slowly started to appear. When I got back home, first thing I did was shower. I noticed all these freckles on my legs and lower torso. I looked hard and suddenly realized...

This gets complicated very quickly - or at least it does for me. And I must confess up front that I really don't have a horse in this race. It's just me opining. Regardless, too many question marks confront us for any solidly accurate response. Definitions are important and I'm not sure things...

I'm not sure I agree with that. At the very least, I suspect this is not the same iteration as similar conditions reported in medical annals. I think our ME/CFS is less than 100 years old. There is precedent in Lyme disease. Technically, Borrelia has been around for thousands of years. But...

Immune system signaling is part and parcel of our immune system. This theory presupposes our immune system is in part broken, that the immune signaling switch is stuck in "on" mode, without persistent provocation, and that malfunctioning signaling is in turn causing faulty brain signaling...

This. The brain is involved, and so too is the immune system. Trying to unravel our symptom stew can be daunting, but I think I prefer the simpler answer: Our immune system is the chief culprit behind our symptoms - as it is with most diseases.

I'm sorry, it was late for me eight hours ago. I believe in the persistence theory. I believe that's what makes us sick, fools us lab wise. A pathogen tandem abrogates our immune system, it snips the wiring so to muffle the alarms. But I also think, paradoxically, our immune system is making...

Yep.

Even if the immune didn't think so? If it never had been activated? If it had been duped? Thank you @paolo.

@paolo , quickish question: What if ME/CFS is not simply an ongoing, and unique "virgin" and unqualified disease, but instead is an enduring end-point that can be reached through any number of mechanisms, most of which might be explained by pathogen persistence - and the persistent agent can...