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    Medscape article: No Evidence Supports Using Graded Exercise for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

    "While some of the studies found positive short-term improvements, results were generally inconsistent. Moreover, Wormgoor pointed out that most of the studies reflected several other sources of bias, such as inadequate reporting of adverse events, treatment compliance, or dropout rates...
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    Medscape article: No Evidence Supports Using Graded Exercise for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

    My presentation focused on the methodological limitations underlying claims of effectiveness of activity-based interventions for ME/CFS. The journalist, Miriam Tucker, chose to highlight the fact that only one study applied appropriate diagnostic criteria. She did not go into the methodological...
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    Medscape article: No Evidence Supports Using Graded Exercise for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

    You are of course right that “exertion intolerance” and “post-exertional malaise (PEM)” are not identical concepts. In this case, the phrase was used in the introduction of a talk at the IACFS/ME conference, where one can assume the audience is familiar with what PEM is. The intention was not to...
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    What would a good questionnaire for diagnosing PEM look like?

    Good questions! How did DecodeME use this to determine whether a patient has PEM? Did they require a positive response to both of the first answer options? The PEM-questions of Decode2 are great as well, I think: Symptoms after effort or activity 8. Do you experience post-exertional malaise...
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    The evidence base for physiotherapy in myalgic encephalomyelitis/chronic fatigue syndrome when considering PEM: a systematic review (2020) Wormgoor

    In the paper, the NICE criteria were assigned to the 'optional PEM' group, see table 4. According to the 2007 NICE guidelines, fatigue with post-exertional malaise and/or fatigue was one of the features that needed to be present. However all other core symptoms were optional.
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