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GIGO still applies. Garbage in, garbage out. If the AI feeds on medical opinion then the quality of the opinion matters. As does the quality of studies. As does the volume of studies. If poor science dominates due to financial or other interests, it will have a tendency to bias the AI response...

Agree. High genetic heterogeneity is only a problem is there is high downstream causal heterogeneity. If a huge number of genes have potentially a small impact on the pathological mechanisms, but the mechanisms are conserved, the focus should be on those mechanisms. Now metabolomic, RNA and...

Pieces of this argument might make sense but still have to be proven. Adverse childhood experiences are a reach beyond sound evidence. However brain immune activation and other stressor signals during viral infection that crosses the blood brain barrier, or even just from chemical signals that...

I am currently somewhere on the low severe range, not very severe. Fatigue, such as it is, never stopped me doing anything. I could always push through. This is a huge problem if not controlled, as it can lead to a crash, whether I call it PEM or PESE or whatever. I used to think fatigue is...

I am currently in favor, and have been on and off for heading toward 30 years, that in ME (not specifally LC) its more a dynamic dysfunction, caused by signaling whether neurological or biochemical. I suspect that something similar applies to LC but with Covid there could easily be surprises.

The cause is yet to be determined, but I am intrigued by the Locus Coeruleus hyperactivation and failure to produce norepinephrine. If confirmed this is possibly the smoking gun we have been looking for. Its probably linked to signals from overactive microglia. Its a specific molecular target...

Yes, exactly. Sudden remissions are known in many of us. So is sudden decline. Any model that does not allow onset or remission within hours is wrong for at least some of us. Similarly ME can hit the first time within a few hours. Finally, there was recent research showing minimal muscle...

I have told this story so many times, hope its new to most of you. Coming home from uni during my biochem degree, I had to walk up a hill. I was going very slow. I was about 40, but with moderate ME, at the end of many hours at my university. Suddenly I heard a clacking sound from behind me...

Age and ME are different in this respect. Using the Perikles approach I have been able to do a little resistance training for over a year now. I choose weight that means I can exercise for about thirty seconds, stop if I am breathing heavily, change muscle groups the next time, and between I...

Until we have successful clinical trials, including at least phase 3 trials of treatments that work on most patients, there are no proven treatments. All a properly aware doctor can do is acknowledge the issues and work with you rather than prescribing dubious or dangerous treatments. There are...

Helicobacter pylori. After this cause of gastric ulcers was identified it took maybe ten years for every GP paying attention before it was common. More on that in the next para. It took maybe twenty years before nearly all doctors were aware, and prescribing appropriate antibiotics. What made...

At the time I was concerned it would do harm, and said so to various people. I wonder how all the adverse events were handled, and what they were.

I wish they would stop, I don't need that much TP.

This is not about empathy from the first post. This is about brain sensitivity to stimuli. So it may select those on the autism or ME spectrum, and probably other disorders affecting the brain. Its too soon, based on the first post, to tell if its a genuine finding or just more psychobabble...

ME being involved with eicosanoid synthesis dysregulation was a central feature of the hypothesis of Dr Andriya Martinovic in the early 90s. He was my doctor at the time and published maybe four papers on the hypothesis. He never got funding for further testing of the hypothesis.

Of course, say they, it might be that the retraining was not quite right, either in formulation or delivery, so it might work next time? Right? In that light I would like to promote the idea of an exorcism. I mean there is no evidence that will be any help at all, but when has that stopped them...

Pay attention to the cost savings. I have been predicting for years that AI will transform the medical system, most docs can be replaced by nurse practitioners at a fraction of the cost, though I think new qualifications will be created. This is in part corporatized medicine, but also insurance...

You = Me = deep chuckle

I started this journey into disability as a pro-authoritarian and pro-medical doctor supporter. Failure after failure from authority figures, especially doctors, left me highly skeptical. I am now asking why research is so often ignored, including research failures. I second guess everything a...

Hypothetical - If your whole life is a waking nightmare, and keeps getting worse, how much worse is a PTSD flashback? The past was better than now. However during recovery, whenever we find a cure or if you are one of the lucky few, PTSD might substantially delay recovery. These are questions...