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@Sean, my apologies. I know better. I couldn’t read it either. I tried using the "paper formater” software that some nice person (whose name I forgot) here on the forum created to make the process of posting a paper easier and I did not review that mass of text for readability. Thanks for...

@Jonathan Edwards, I should know better than to question your diagnostic descriptions , but did the "chronic widespread unexplained pain" include joint pain? I always assumed the fibromyalgia diagnosis excluded joint pain and was chronic widespread unexplained neuromuscular pain, but I am a lay...

Effects of Motor Imagery on Movement-Based Fear in Musculoskeletal Conditions: A Critically Appraised Topic Abstract Clinical Scenario : The presence of movement-based fear during rehabilitation negatively impacts injury recovery, quality of performance, and perceived disability. While...

How about a discussion of pros and cons of (and engaging of interest in) a world-wide whole genome sequencing study?

FWIW, in DecodME 86.1% of the cohort reported "muscle pain".

Ranma, My original symptoms also started as repetitive stress symptoms from keyboard and mouse overuse.

@LizWorthey, I am reading your interchanges with great interest. Thanks for participating. FYI, here is the thread on S4ME on FBXL4: https://www.s4me.info/threads/genetics-fbxl4.45509/

This is a long video about the current intricacies of the United States healthcare system and the realities of appealing a denial of service by your health insurance company. The man being interviewed, Warris Bokhari, has started a company that uses AI to prepare a appeal to a denial of...

Associations Between Genetic Polymorphisms and Psychological Variables in Women With Fibromyalgia: A Cross‐Sectional Study, 2025, Riquelme‐Aguado et al. ABSTRACT Introduction Fibromyalgia (FM) is a multifactorial syndrome involving chronic pain and psychological distress. Psychological traits...

Jonathan, I have long wondered about the validity of this research paper on Fibromyalgia from 2013. It discusses ischemia a bit. Are you familiar with it? Excessive Peptidergic Sensory Innervation of Cutaneous Arteriole-Venule Shunts (AVS) in the Palmar Glabrous Skin of Fibromyalgia Patients...

It is a reformularion of flexeril (cyclobenzaprine) - a common, inexpensive muscle relaxer pharmaceutical. The study is worth perusing. I do wonder what will be the price when it rolls out in other countries.

For USA pricing, I did a search on "GoodRX". current pricing is listed as $1850-$2150 for a one month supply. Welcome to the wonderful world of new drug pricing! some Internet searching dug up a comment from Tonix Pharmaceuticals, the drug company selling this product. They said that it would...

what did you learn that can be shared with us?

What sort of activities do you suspect the UCL pain geneticists will undertake?

yes. My gdf-15 test results were negative. Normal value: <=750 pg/mL…. mine = 692 pg/mL. tests were done by the Mayo Clinic Labs in Minnesota, USA.

Abstract This study aims to evaluate the impact of pain catastrophizing (PC) on disease activity in patients with rheumatoid arthritis (RA) and to explore, in the same participants, if this association is related or not with anxiety and depression, which have been related to catastrophization in...

Interesting. I experience an overwhelming"flu like ache" which at times can occur seemingly solely due to a rapidly falling barometric pressure. I live somewhere where large and steep drops in barometric pressure occur in the fall, winter and spring seasons. I have quizzed medical...

I am still reading this… this is a very good summary by some leading researchers about the difficulties they have encountered in trying to develop non-opioid painkillers using the sodium channel Nav1.8. It’s been a difficult and perplexing process and there’s an immense amount of pressure to...

interesting and odd. Just a reformation of Flexeril?? Here’s a link to the companies publication in the journal, “pain medicine”: https://academic.oup.com/painmedicine/advance-article/doi/10.1093/pm/pnaf089/8193722 Here is the graph from the paper of the Primary efficacy endpoint, a daily...

Abstract Fibromyalgia is a common and debilitating chronic pain syndrome of poorly understood etiology. Here, we conduct a multi-ancestry genome-wide association study meta-analysis across 2,563,755 individuals (54,629 cases and 2,509,126 controls) from 11 cohorts, identifying the first 26 risk...