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  1. J

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    Phase 2 is generally the hardest phase to get through. Drugs with a lot of funding behind them and preliminary results that look like a slam dunk frequently don’t make the cut. From AI: The overall likelihood of approval (LOA) for a drug entering Phase I clinical trials is low, generally...
  2. J

    News from France

    “ 30 million is a rounding error in modern science — well under 0.1% of the NIH budget — yet it’s being framed as a civilizational pivot. France (and much of Europe) already struggles with entrenched cronyism, groupthink, and reproducibility problems in its research institutions. Adding a...
  3. J

    Sleep disturbance triggers aberrant activation of vagus circuitry and induces intestinal stem cell dysfunction 2026 Zhang et al

    Highlights • Sleep deprivation triggers intestinal stem cell dysfunction and gut pathologies • Overactive dorsal motor nucleus of vagus transmits sleep defect signals to the gut • Excess acetylcholine from vagus nerve triggers 5-hydroxytryptamine spike in the gut • Elevated 5-hydroxytryptamine...
  4. J

    Daratumumab in systemic lupus erythematosus: a single-arm phase 2 trial, 2026, Ostendorf et al

    Do Americans not eat marmalade? FOOD & DRINK I was buying marmalade at my local Safeway yesterday, and the cashier said, "Ooh, marmalade! No one buys that. I like it, myself, but I've never seen anyone else buy it". My husband and I are imports, we grew up British so we brought our weird...
  5. J

    Daratumumab in systemic lupus erythematosus: a single-arm phase 2 trial, 2026, Ostendorf et al

    Is this U.K. speak meaning that this statement is obvious?
  6. J

    Trial Report REGENECYTE cord blood cell therapy in post-COVID syndrome: a phase IIa randomized, placebo-controlled trial, 2026, Huang et al

    No—Topol is actually (shockingly) being good/helpful here. He is criticizing Attia for hawking this bogus AG-1 supplement and these David protein bars, etc. “Moreover, these days you are riddled with conflicts as a huckster for David Bars, AG-1 supplement, and so many other things that diminish...
  7. J

    Trial Report REGENECYTE cord blood cell therapy in post-COVID syndrome: a phase IIa randomized, placebo-controlled trial, 2026, Huang et al

    Happening right now—google Peter Attia. He is getting dumped on for the main thing in the news, but also a result of being in the news, people are criticizing his bogus longevity claims. Here is Topol attacking Attia: “ Good that you posted a response, Peter. Agree, there is no defense for...
  8. J

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    Not really. Well working with very small sample sizes here. For non-responders: Patients 3 and 9 weren’t able to reduce IGG much—8.2 and 7.7 at 5 months. Patient 4 was able to reduce IGG to 3.7 at 5 months but started at the lowest level—6.8. By month nine patient 6 was above 7 and the...
  9. J

    Review POTS, ME/CFS and Long COVID as Neuroimmune Disorders, 2026, Blitshteyn et al

    Svetlana disagrees. Hot off the press: my new paper that moves this field forward and changes the narrative on what #POTS, #MECFS and #LongCOVID are... Neuroimmune Disorders! The brain and the autonomic nervous system are involved in the immune system regulation. There is evidence of...
  10. J

    Vagus nerve-mediated neuroimmune modulation for rheumatoid arthritis: a pivotal randomized controlled trial 2025 Tesser et al

    Merged post https://substack.com/@erictopol/note/c-208424475?r=7y4i4&utm_medium=ios&utm_source=notes-share-action Might be of interest to @Jonathan Edwards
  11. J

    Intestinal permeability correlated with chronic fatigue in a patient with long COVID—A case report and overview of the literature 2026 Andus

    Only if you live in Europe. The clay and the pro-biotic are German. https://www.gosupps.com/luvos-healing-clay-imutox-powder-380-g-powder.html https://en.wikipedia.org/wiki/Medicinal_clay
  12. J

    Intestinal permeability correlated with chronic fatigue in a patient with long COVID—A case report and overview of the literature 2026 Andus

    Background: Long COVID is a complex condition characterized by persistent symptoms such as chronic fatigue, cognitive impairment, and autonomic dysfunction. Emerging evidence suggests that the gut may play a role in the pathophysiology of long COVID, potentially contributing to systemic...
  13. J

    Well known, famous people reported to have Lyme Disease.

    He thinks HBOT will cure him
  14. J

    Daratumumab in severe Evans syndrome: a case report 2026 Hillmann et al.

    Evans syndrome is a rare autoimmune disorder characterized by the simultaneous or sequential occurrence of autoimmune cytopenia. The disease is chronic, relapsing, and frequently refractory to standard therapies. Typical symptoms include anemia-related fatigue, pallor, and jaundice due to...
  15. J

    There aren’t any answers, we are looking for them and will support you until we find them

    No. There are no APPROVED treatments. Saying there are no effective treatments is an opinion. Saying there are no officially approved treatments is a fact.
  16. J

    Preprint Disruption of the hypothalamic orexin system links SARS-CoV-2 infection to persistent cortical neuronal pathology, 2026, Yoon et al.

    Off topic, but do you feel quiviviq helps with your sleep?
  17. J

    Well known, famous people reported to have Lyme Disease.

    Musk responded to him.
  18. J

    The new vision from the National Institute of Allergy and Infectious Diseases (NIAID), 2026, Taubenberger et al.

    Inexcusable that they published this 100% taxpayer funded article behind a paywall.
  19. J

    Opinion The lingering shadow of epidemics: post-acute sequelae across history, 2025, Miller, Iwasaki+

    'Our review is highlighted by the cover of the current issue of @TrendsImmuno -The lingering shadow of epidemics: post-acute sequelae across history by Christine Miller and @jannamoen. Please read (open access)'
  20. J

    Chinese Universities Surge in Global Rankings as U.S. Schools Slip

    Probably so. But the article also mentions other metrics, But there is no doubt Chinese research is ascendant. See this recent NEJM article I posted…100% Chinese authors/institutions. https://www.s4me.info/threads/cd19-car-t-cell-therapy-for-autoimmune-hemolytic-anemia-2026-li-et-al.48312/
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