@Jonathan Edwards Any idea why the number of NK cells is (or might be) more important than NK cell activity for response to Daratumumab? Thanks.
Also baseline IGG level didn’t matter with respect to response—that’s a shocker!!
Responders like 7-8k steps. From like 3k baseline.
Fluge—patients with low NK cells at baseline ~100 or less were non-responders. In phase 2 will only include patients with >125 NK cells.
[MEDIA] Øystein Fluge,Norway, on plasma cell targeting in #MECFS: Daratumumab (anti-CD38) shows clinical &objective improvement in 60% of...
Isn’t it bad to deplete your microglia? Don’t you need them around?
Highlights • CAR T cell therapy for CNS and non-CNS cancers can impair cognition in mice • CAR T cell therapy induces white matter microglial...
[MEDIA] Jürgen Steinacker, Ulm Muscle biopsies show: Mitochondria are structurally damaged in #MECFS and PCS – cristae destroyed, sarcomeres...
[MEDIA] Wust Muscle changes in #MECFS & LongCovid are pathological – not caused by deconditioning. Exertion above the #PEM threshold causes...
[MEDIA] David Systrom, USA, on circulatory dysfunction in #MECFSPatients show impaired systemic oxygen extraction & small fiber neuropathy-...
[MEDIA] Prof. Kristian Sommerfelt (Norway) shared devastating data: 50% of severe #MECFS patients worsened over time. 0% of very severe ME...
[MEDIA] At the #MECFS Conference 2025, @C_Scheibenbogen highlighted striking findings: immune dysregulation, muscle damage, and autoantibodies in...
[MEDIA] Report on Porzingis.
Any more info from this meeting re Fluge’s talk?—I thought some of the folks here knew people who attended @Kalliope @sneyz @Marky Thanks
Possible for anyone to record the livestream on Tuesday morning with the Fluge and Mella talks —starting 920 am German time? Thanks to anyone who...
A bit off topic, but I’m not in love with the word pesticide because a lot of people think this means insecticide. Golf courses are heavy users of...
[MEDIA] ME/CFS and Long Covid - Digging Deeper - in Norwegen, sehr guter Austausch mit Brian Hughes, Oystein Fluge, Kristian Sommerfelt,...
OK but Fluge and his group are not stupid—they’ve learned from the ritux trial. E.g, they are measuring steps, which I don’t think they did in the...
Can go from phase 2 to approval https://ascopubs.org/doi/10.14694/EdBook_AM.2012.32.114
Long interview with NYT here...
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