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I see that your Cluster_1 points to glutamatergic synapses, which is particularly interesting. Patients frequently report alcohol intolerance. This could be explained by the inhibitory effect of alcohol on NMDA receptors: under the hypothesis of deficient glutamatergic transmission, alcohol...

Hi, I developed the MetaME and DecodeME repositories on GitHub. I am not a scientist, just a patient. MetaME is a meta-analysis of approximately 21,500 ME cases (DecodeME + UK Biobank + Million Veteran Program). It uses standard methodologies (METAL + FUMA). No fine-mapping was performed. The...

Any idea about what tissue the gene expression assay was performed on? Were fat tissue and muscle biopsies included in the NIH intramural study?

Is it possible that there is something in plasma from patients that triggers microclots growth around it, under lab conditions? Something that would trigger the formation of microclots even in plasma with normal clotting activity.

It seems that dr. Pretorius is also involved in patents for treatments of blot clots in Alzheimer's disease, Parkinson's disease, and type 2 diabetes (this page, bottom).

In this blog post there is a link to the video with English subtitles.

Thanks for mentioning my blog post. I searched for a way to better understand the trap hypothesis and I found the mechanical analogy.

@Sly Saint Thank you for sharing my blog post! It has been really a pleasure for me to discover this 'old' study and to write about it. We didn't have much mathematical modelling in ME/CFS and I hope there will be a lot more in the future. The link is wrong, the correct one is...

Ok, so now I have understood what you meant, sorry. I don't know the answer. It would be interesting to see this kind of test for MS, yes. Someone previously did a test like this for post-treatment lyme disease syndrome (PTLDS) and it turned out to be similar to Lupus, more than it is to ME (R).

They have considered data on all sort of diseases, I guess. So, as MS is not on the list, it probably means that the score of the comparison between MS and ME is below 79%. The same applies to healthy controls. The bottom line is that ME seems like systemic inflammatory response syndrome and -...

This is a study of gene expression: they have studied which genes are expressed by peripheral blood white cells in their severe ME patients (and how much each gene is expressed) and then they have searched for similarities with what we know about gene expression in known diseases...

Hi! Here I am. Thanks for sharing!