Sorry to be late in responding. The analysis for Figure 5 considered the association of 80 symptoms as well as age and sex in the same model. The...
Every human on earth carries deleterious changes to their genes. This person has several such changes, and the authors focus on only 1, to ADCK1,...
Yes - please email me if/when funding is announced for SequenceME.
Also: "Oxford Nanopore’s breakthrough genetic sequencing tech to analyse 50,000 samples from UK Biobank, to create a world-first ‘epigenetic...
Right on cue, a preprint came out today that spells out the benefits of applying both GWAS and Whole Genome Sequencing:...
With one voice we ask the UK Govt (and other governments), and their funding agencies, to strategically prioritise ME/CFS research funding. If not...
In no particular order here are a dozen: (i) rare DNA differences causing disease (found using whole genome sequencing), rather than the common...
Thank you, Simon. But what you don't say is how you came to my rescue a decade before. This is what friends do - when they can - and Simon did...
Yes, these are NDE values in the units measured for gamma glutamyltransferase (U/l) and are not Z-scores. See above. Thank you.
Not at all, we were not clear. For each trait (e.g. Chylomicron concentration) we have estimated the Natural Direct Effect (NDE) and it is this...
Copied post In DecodeME we see a female/male ratio of 5-to-1 (https://openresearch.nihr.ac.uk/articles/3-20), and across all ICD10 G93.3 codes in...
In DecodeME we see a female/male ratio of 5-to-1 (https://openresearch.nihr.ac.uk/articles/3-20), and across all ICD10 G93.3 codes in England we...
As an author, I'd really welcome any suggestions that might improve how this paper describes the science - including, for example, citations in...
Hello all. Here's a new PPI opportunity to be involved in a short-term project: Project Description: Our project aims to investigate the...
Thank you @Andy . A request for 2 PPI members: · ME/CFS-related Immune Research Project based at Imperial College. Proposal not currently...
Thanks. We've looked in UK Biobank data and don't see low alkaline phosphatase levels on average. If anything it might be slightly higher.
Next steps for genetics are: (1) Replication in an independent cohort, (2) Joining forces with other projects to do a meta-analysis and (3)...
Variant rs10191329 (minor allele frequency 17%) near to genes DYSF and ZNF638: p = 9.7x10-9 (whereas the usual significance threshold is...
We still need many more people. In part this is because we don't receive samples for all people sent a kit. The rate of sample kit returns is...
Unfortunately, when we asked 23andMe for their help (using their date), the male PDE10A signal did not replicate. So we need to look again once we...
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