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An SF 36 physical function of under 30 is lower than usual in clinical cohorts, I think. IIRC, the pace trial was mid 30s. Similarly, 97.5 is above average for the population. Maybe that's because it's specifically healthy controls, but it looks like there's been no attempt to control for...

I think that's the key point: we need replication. These are all interesting findings. But there are hundreds, if not thousands, of interesting findings out there. Almost none of them have been replicated, so we can't rely on them. What we need are more independent replications, like this...

Maybe it's that, I think I've seen a presentation suggesting the trials would be underway by now. I thought I'd also read that they had sorted the genetic test they need to identify sub groups protesting. But I haven't seen any confirmation that those trials are in progress – that was an...

I find that surprising, even though the combinatorial method, in theory, is able to find true results from much smaller samples. The big problem I see in saying that a gene or genes explains the symptom of any subgroup is that these are SNPs. Snips are common variants , which indicates they...

I don't know how significant this is. I quite often don't have symptoms at rest, but I always have the problem of minimal exertion exhausting me. In other words, if the problem was that something in my blood was stopping my mitochondria working properly, I would've expected that something in the...

I didn't hear the talk, but understand that she and @chillier attempted to replicate the most robust/replicable 'something in the blood' finding, and could not Negative replication results are so important because they stop the field from having endless possible theories. Culling things that...

As we have year of onset, we could look at 2009/10 in isolation.

Thanks for bearing with me, @Jonathan Edwards. My brain is in slightly bit of shape this evening, so I’ll try one more post. my brain is doing better this evening, so I’ll try again in response to your points. First of all, it would be wonderful if everything amounts to signalling issues –...

Yes and no - for me at least pain and fatigue and not the only thing that limit our ability. This goes to the heart of psychosocial and biopsychosocial views of the world and what we need to do to recover, at least as I understand them. I hope I make more sense below: Pain and fatigue exist...

Thanks. That’s possible, though the participation rate was lower than for the Nordic countries, and my understanding is that The survey was promoted by the main ME organisation. I’m guessing If this happened, we might see it in the age survey, Which we will look at, as above.

Good question – we have the information and will check ( from memory, countries were pretty similar, but my memory isn’t so good).

Thanks for the insights. that’s interesting.

Just checking I’ve got this right – you’re saying there is a faint possibility that the neuro signals are not false, and are actually contributing to the problem, possibly (Via interferon gamma receptors on synapses and neurotransmitter receptors on T cells). But it sounds like it’s more...

Thanks. It is interesting, even if because it doesn't seem to explain the data.

I’ll be interested to hear what Julie Newton says. It was also PhD, she using some kind of 3-D Muscle cell culturing technique, with electrical stimulation, designed to give more realistic results. But that found very little and the PhD author decided it showed that CBT was the answer (despite...

Thanks for the reply. Yes, that's the sort of thing we were wondering. We haven't seen a different trigger pattern in the Netherlands (such as more or fewer infections). I should have mentioned that surveys were primarily distributed on social media across Europe. The response in the...

This appeared to be a promising line of inquiry when it came out (I'm pretty sure Julia Newton presented about this work at the conference). But either it wasn't followed up, or perhaps it was and proved a dead end, with results not published. That has often been the way of things.

I'm trying to understand this. Are you saying that there is (or could be?) a false/exaggerated signal and that the signal is amplifying the immune signal associated with damage? I'm not sure I have got this right.

Apologies, I had left out the link to the EMEA survey. https://www.euro-me.org/emea-pan-european-survey-uk.shtml Yes, the survey was promoted by European national ME organisations. As such, it is only likely to be seen by those with a diagnosis; those without are unlikely to be covered...

Perhaps we should be cautious in relying on genetic explanations for a disease with only weak heritability.Almost everything that will come up in any GWAS will be common (so widespread in the population) and with a weak effect (though the effect is most likely to be on gene expression). Many...