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  1. Simon M
    Post

    News from The Netherlands

    I'm hoping this is a good place to ask about diagnosis practices in the Netherlands. Along with Audrey Ryback (a researcher at Edinburgh in...
    Post by: Simon M, Today at 6:45 PM in forum: Regional news
  2. Simon M
    Post

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    @Jonathan Edwards, did you see this? I’ll be interested in your response (apologies if you responded and I missed it)
    Post by: Simon M, Today at 9:14 AM in forum: ME/CFS research
  3. Simon M
    Post

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    I'm assuming the RA/Lupus/omplement example also ties in with your point about making all the details fit. I don't think they looked at onset time...
    Post by: Simon M, Thursday at 8:12 PM in forum: ME/CFS research
  4. Simon M
    Post

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    @Jonathan Edwards, thanks to you, Jo Cambridge and Jackie Cliff for putting together such a thoughtful model that, at the very least, shows how a...
    Post by: Simon M, Thursday at 5:56 PM in forum: ME/CFS research
  5. Simon M
    Post

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    I wonder how relevant neural hypervigilance is. (If I’ve understood right, that’s the basic idea of the interception hypothesis, which a few...
    Post by: Simon M, Thursday at 8:46 AM in forum: ME/CFS research
  6. Simon M
    Post

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    That’s pretty depressing, if unsurprising. Thank you for putting your head above the parapet when you know what is flying your way. I don’t know...
    Post by: Simon M, Thursday at 8:41 AM in forum: ME/CFS research
  7. Simon M
    Post

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    which is itself a very helpful step. Up till now, it’s mostly consisted of “ Here is our finding. Here is how it could explain an aspect of the...
    Post by: Simon M, Wednesday at 6:55 PM in forum: ME/CFS research
  8. Simon M
    Post

    Defining a High-Quality Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cohort in UK Biobank, 2025, Samms & Ponting

    C2: Self-report of ME/CFS from the pain questionnaire, 2,720 people. I'm starting with this cohort as it's the most extreme and also has data...
    Post by: Simon M, Tuesday at 7:52 PM in forum: ME/CFS research
  9. Simon M
    Post

    Defining a High-Quality Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cohort in UK Biobank, 2025, Samms & Ponting

    Some comments on the validity of each cohort, adding to what the authors say and what has been posted here to date. General point The cohort...
    Post by: Simon M, Tuesday at 7:49 PM in forum: ME/CFS research
  10. Simon M
    Post

    Defining a High-Quality Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cohort in UK Biobank, 2025, Samms & Ponting

    I saw the other quote—it is confusing! But see Fig 2, whose data implies that Yes, No, No is the right answer.
    Post by: Simon M, Tuesday at 11:40 AM in forum: ME/CFS research
  11. Simon M
    Post

    Defining a High-Quality Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cohort in UK Biobank, 2025, Samms & Ponting

    The paper Says that answering these three questions “yes, no, no” is consistent with PEM– Aren’t you agreeing? I agree that those questions...
    Post by: Simon M, Tuesday at 10:20 AM in forum: ME/CFS research
  12. Simon M
    Post

    Defining a High-Quality Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cohort in UK Biobank, 2025, Samms & Ponting

    Cohort quality assessed by cohort overlap Those in C3 (hospital G93.3 code) come out best, C2 (PQ ME/CFS) worst The simplest way the study...
    Post by: Simon M, Monday at 10:35 AM in forum: ME/CFS research
  13. Simon M
    Post

    The Relation Between Cardiac Output and Cerebral Blood Flow in ME/CFS Patients with a POTS Response During a Tilt Test, 2025, van Campen et al

    Thanks – and I just didn’t want you to think that I hadn’t even bothered to read the abstract (where the acronyms are spelt out) before asking a...
    Post by: Simon M, May 24, 2025 in forum: ME/CFS research
  14. Simon M
    Post

    The Relation Between Cardiac Output and Cerebral Blood Flow in ME/CFS Patients with a POTS Response During a Tilt Test, 2025, van Campen et al

    Thanks very much for that. I was also struck by the clean separation for biological variables – like you say, that’s pretty rare. Unless there’s a...
    Post by: Simon M, May 24, 2025 in forum: ME/CFS research
  15. Simon M
    Post

    The Relation Between Cardiac Output and Cerebral Blood Flow in ME/CFS Patients with a POTS Response During a Tilt Test, 2025, van Campen et al

    Look neat analysis For the benefit of those of us not keeping up with this work, would you be able to explain what we are seeing here that is...
    Post by: Simon M, May 24, 2025 in forum: ME/CFS research
  16. Simon M
    Post

    Defining a High-Quality Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cohort in UK Biobank, 2025, Samms & Ponting

    Where is missing data missing from, and why? Summary: All UKB participants have baseline assessment data (with self-reported serious illnesses),...
    Post by: Simon M, May 23, 2025 in forum: ME/CFS research
  17. Simon M
    Post

    Preprint Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+

    Sorry, I haven’t been keeping up. Interesting analysis But 28% of that group reported good or excellent health, and they were other issues –,...
    Post by: Simon M, May 21, 2025 in forum: ME/CFS research
  18. Simon M
    Post

    Preprint Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+

    Thanks for the responses, @forestglip and @jnmaciuch. My concern about AUC wasn't anything to do with diagnosis (it's too low to be useful), but...
    Post by: Simon M, May 21, 2025 in forum: ME/CFS research
  19. Simon M
    Post

    Preprint Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+

    Could you just spell that out, please. My first quote is from the para, which begins with a discussion of simulations and concludes with the data...
    Post by: Simon M, May 18, 2025 in forum: ME/CFS research
  20. Simon M
    Post

    Preprint Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+

    Like you, I find the discussion fascinating, especially after 30 years with little happening in research. But maybe this is the time to raise...
    Post by: Simon M, May 18, 2025 in forum: ME/CFS research
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