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  1. wastwater

    Genome-wide Association Study of Long COVID, 2023, Lammi et al.

    https://pmc.ncbi.nlm.nih.gov/articles/PMC12255186/
  2. wastwater

    Genome-wide Association Study of Long COVID, 2023, Lammi et al.

    A genetic risk factor for the development of #LongCovid!A new study identified the first genome-wide significant association for #LongCOVID at the FOXP4 locus. 1/
  3. wastwater

    The ruling out of other conditions: do you think you've had adequate ruling out of other conditions?

    I kept looking for alternatives. And wondered if it may be something else rare like these but it’s confusing and many include MRI imaging findings Could mecfs lc somehow be in here too or not COL4A2 was mentioned in a gene study relating to long Covid on here...
  4. wastwater

    Long Covid Doctor, Dr Tim Robinson, South west UK

    https://www.h4c.org.uk/courses-all/lc-100925
  5. wastwater

    Long Covid Doctor, Dr Tim Robinson, South west UK

    https://m.youtube.com/@longcoviddoctor
  6. wastwater

    Preprint Genome-wide association studies of Long COVID and post-acute complications of SARS-CoV-2 in the UK Biobank Data, 2025, Prieto-Alhambra et al.

    If long Covid pulled out FOXP4 as a risk factor maybe the decode Me pulled out the targets of FOXP4
  7. wastwater

    Preprint Long COVID Risk Loci Implicated from Genome-Wide Association Studies of COVID-19 Susceptibility and Hospitalization, 2025, Cheng

    https://pmc.ncbi.nlm.nih.gov/articles/PMC12255186/
  8. wastwater

    Independent: Father attempted suicide and family almost lost home after GP missed common genetic condition for six years

    Genetic low iron desease https://en.wikipedia.org/wiki/Plummer%E2%80%93Vinson_syndrome
  9. wastwater

    Independent: Father attempted suicide and family almost lost home after GP missed common genetic condition for six years

    It is a rare genetic disorder of abnormal lymphocyte survival caused by defective Fasmediated apoptosis.<a href="https://en.wikipedia.org/wiki/Autoimmune_lymphoproliferative_syndrome#cite_note-pmid16522544-3"><span>[</span>3<span>]</span></a> Normally, after infectious insult, the immune system...
  10. wastwater

    Independent: Father attempted suicide and family almost lost home after GP missed common genetic condition for six years

    https://en.wikipedia.org/wiki/Leukoencephalopathy_with_neuroaxonal_spheroids?fbclid=IwY2xjawN7xSFleHRuA2FlbQIxMQBzcnRjBmFwcF9pZA80MDk5NjI2MjMwODU2MDkAAR5PvsKMeVlUj4-M8KNZ5hTmDAsVAW3XCA3kWgkIKpzZMsYyqcKIkJ87DttCiw_aem__3p24WtGQs3-9-oRD_EKfA
  11. wastwater

    Is the key pathology of ME/CFS in bone marrow?

    I just asked chat gpt and that’s what it came up with I just word match,I don’t understand much of it
  12. wastwater

    Is the key pathology of ME/CFS in bone marrow?

    Excellent question — you’re now asking about transcription factors that regulate the expression of TLR7 itself (i.e., what turns the TLR7 gene on or off), rather than those activated downstream of TLR7 signaling. Here’s a detailed overview: Transcriptional Regulation of TLR7 (Upstream...
  13. wastwater

    Is the key pathology of ME/CFS in bone marrow?

    Toll-like receptor 7 (TLR7) is a pattern recognition receptor that detects single-stranded RNA (ssRNA), often from viruses, and triggers downstream signaling pathways that induce innate immune responses — particularly type I interferon and proinflammatory cytokine production. Here’s a breakdown...
  14. wastwater

    Is the key pathology of ME/CFS in bone marrow?

    PAX6 and FOXO1 are the genes I come up with EBV lowers FOXO1 expression
  15. wastwater

    Development and validation of blood-based diagnostic biomarkers for [ME/CFS] using EpiSwitch®… 2025, Hunter et al. (Oxford Biodynamics)

    https://studyfinds.org/blood-test-achieves-accuracy-diagnosing-chronic-fatigue-syndrome/ In A Nutshell A 3D-DNA blood test (EpiSwitch CFS) identified ME/CFS with about 96% accuracy in a small validation study. The strongest signals involve IL-2 and other immune-signaling pathways, hinting at...
  16. wastwater

    The genetic architecture of fibromyalgia across 2.5 million individuals, 2025, Kerrebijnet al.

    Gpr52 links to schizophrenia as well https://jpet.aspetjournals.org/article/S0022-3565(24)42361-6/abstract GPR52 Constitutively Activates Multiple G Proteins and Beta-Arrestin2: Insights for Orphan GPCR Signaling (Abstract ID: 167613) Jones Addiah-Nickson ∙ Ryan E. Murphy ∙ John A. Allen...
  17. wastwater

    [uniQure] Positive Topline Results from Phase I/II Study of AMT-130 in Patients with Huntington’s Disease

    Oddly enough I’m probably paralleling something more like this now
  18. wastwater

    Microvascular Dysfunction and Basal Membrane Thickening in Skeletal Muscle in ME/CFS and Post-COVID, 2025, Slaghekke et al

    Merged posts ----------------------
  19. wastwater

    SGLT-2 inhibitors to become first-choice treatments for type 2 diabetes

    https://www.diabetes.co.uk/news/2025/aug/sglt-2-inhibitors-to-become-first-choice-treatments-for-type-2-diabetes.html Draft NICE guidelines propose upgrading Sodium-Glucose Transport Protein 2 (SGLT2) inhibitors from second choice to first-choice treatments for type 2 diabetes.
  20. wastwater

    PITX2 deficiency leads to atrial mitochondrial dysfunction, 2024, Reyat et al (atrial fibrillation)

    What happened to FOXO1 in mecfs as it was mentioned in the past
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