Can study them inside live samples from patients - easier or harder depending on the tissue of interest. We have done it in circulating immune...
"mtDNA analysis from muscle at 46 years of age revealed the m.8753_16,566 deletion with <10 % heteroplasmy. The deletion was larger than in...
mTORC1 activation as a primary upstream factor driving the disease (across which compartments - the whole body?) doesn't seem to fit with a lot of...
we have a PhD student who is characterising cell lines from people with mutations to genes encoding complex V subunits, and who is also...
Yeah this was the really big one from Prof Gras' lab on the topic
increasingly important to nail down the causal relationships since this is all bi-directional feedback
Hello all. I am going to plug something I am not directly part of or leading but collaborate with - since I can't see anything about it on this...
One of the team members is a bioinformatician with a pipeline that can screen biological features of interest against libraries of approved drug...
I don't know where this narrative in the video of "mitochondrial abnormalities haven't been found in 'blood cells' but have been found in muscle...
My speculative 2c. In addition to what forestglip has said, which is a good reply, my view is that most of the stuff that has been found...
not all of the publications would necessarily be open access so some things would have to be excluded
Thanks for reposting here. I am trying to be rigorous with the cohort selection so there is a bit of an attrition rate and getting the last few...
This and factoring in PEM I think is important here May I ask you to please elaborate on this concept of a decoy? (glad you went in this...
Fingers crossed that this all leads to something, but since a lot of cell biology is controlled by TOR signalling in the broad sense (possibly...
You may always feel free to send me whatever you like I can't guarantee that I will physically have enough time to go through everything as...
Sorry, I deleted my comment right as I realised that they did describe it (just not next to the test outcomes as I expected, so I missed it) but...
Agreed and this is why I refrained from overanalysing in the paper absence of more detailed examination - reporting it and moving on seemed best...
Yep! Can indicate or be elicited by other things of course, but yep. It makes sense together.
Scanning it this seems like a good review that got the limitations of my old discriminator paper correct! Fingers crossed that they find success w...
We saw this using RNAseq so whatever small amount there was in that subset of B cells was enough to be quantifiable and different between...
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