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Also from The Guardian, requests for write-ins from sufferers on life with long covid: https://www.theguardian.com/society/2022/oct/12/tell-us-living-with-long-covid?CMP=Share_AndroidApp_Other

Just in case anyone has the same issue as me, I wasn't able to access the participant survey for registration on a Firefox browser, but it worked on a Chrome browser. Might just be my settings on Firefox

I mention omega-3 because the Mediterranean diet is comprised of the foods that provide the highest amounts of this fatty acid (fish, seeds, nuts, leafy veg and some oils), so it could be tricky to distinguish between SCFAs and omega-3s as the source of the improvement in intestinal permeability...

I remember hearing in a lecture that omega-3 fatty acids were the most beneficial dietary component for gut barrier integrity. Found a review that discusses this possibility: Omega-3 Polyunsaturated Fatty Acids and the Intestinal Epithelium—A Review https://doi.org/10.3390/foods10010199

Ken Lassesen has recently posted about this article, and gives a good summary of related studies. https://cfsremission.com/2021/11/02/hypoperfusion-in-the-cfs-me-and-long-covid-brain/ His angle is more towards microbiome involvement which I've seen is also a recent topic of interest on this forum.

I don't know how rapidly our oral microbiome can change/fluctuate. Could that be a factor?

I agree, wouldn't it be best to keep the media dialogue focused on this rather than getting lost in the PACE weeds?

I guess another possibility could be changes in gut microbiota.

Is this what they're planning to use to contest the NICE guidelines?

Touches on ME/CFS

Wow. How much do you wana bet that his wife has been using CFS as an excuse to avoid friday-night fumbles.

No matter how much they say they're feline fatigued

To be fair, there's no funding for cats with ME

Perhaps this endocrine system dysregulation hypothesis could relate to something downstream of a more central pathological mechanism of me/cfs - like hypothalamus inflammation (https://www.healthrising.org/blog/2020/05/27/neuroinflammatory-paradigm-chronic-fatigue-me-cfs/) or problems at the...

Does anyone have any ideas of how PEM could be caused by/connected to dysregulation of the endocrine system? Can't see that discussed in the paper.

Agreed that this definitely seems well worth looking into! Brilliant rationale for me/cfs. On a personal note, when I was admitted to A&E during what I later realised were PEM crashes (before I knew my symptoms were M.E.), my blood checks all came back normal apart from an imbalance of sodium...

A few months back I was reading up on some people's self-reported experience with fecal microbiota transplant and noticed in a couple of occasions the FMT recipient found their issues with white tongue were resolved by the FMT (although this obviously wasn't the objective). I wonder if it...

I do personally know a professor who had to shelve her research into viral involvement in M.E. 20 years ago due to the actions of activists. The grant money was lost and she never researched M.E. again. That said, these are very rare occurrences and obviously aren't a reason for why M.E...

Interesting stuff. Brings to mind this older study with using exogenous ketones but with relevance to metabolism (though not a human study), https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.31.1_supplement.970.7 I also remember reading an article showing that exogenous ketones...