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by Miriam E. Tucker “We face a mismatch around physical activity between established medical practice and what the evidence actually shows. For decades, medicine has worked from the idea that physical activity promotes health and recovery…This underlying idea continues to underpin many...

Paper requested by @V.R.T.

Editor’s summary Lymphocytes, including regulatory T (Treg) cells, tune their metabolism to support their immunological functions. However, the molecular events controlling Treg cell metabolic reprogramming during inflammation are not fully understood. Using a mouse model of acute inflammation...

Apostolos P. Georgopoulos, Lisa M. James & Philip K. Peterson Abstract Viral infections have been widely implicated in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) pathogenesis. Recent evidence has also identified certain Human Leukocyte Antigen (HLA) alleles that are...

I also saw this article about the response of Wallitt et al., so maybe they have sent out a press release (about their own response naturally): Myalgic Encephalomyelitis: Beyond Effort and Deconditioning 'In a compelling and much-needed scientific dialogue, a fresh reply has emerged in the...

Letter responses to the article in the Guardian: Failed by the NHS on chronic fatigue illness One of them is from Prof Paul Garner, Dr Maria Pedersen and Dr Alastair Miller (who would have thought...): "Milly’s exhaustion is typical of a group of conditions known as “persistent physical...

There have been several examples, for example with some organizations (Doctors with ME is something I remember but there were probably more), sometimes researchers or people doing their PhD come to S4ME and take scientific criticism very badly, one example was a questionnaire recently developed...

I do delete posts and even ban repeat offenders from my group when they obviously break the rules. But very often things are not so clear-cut, especially with newer users who may be just naive and inexperienced. I need to cut people some slack, because as I said, my group is quite young, and...

This is a constant problem in my group. It was started in the first year of covid and most people in my group are covid long haulers, so mostly newer patients looking for a cure, blindly trusting every doctor who just mentions "chronic fatigue syndrome" and not many people who already tried...

It is probably the test from the German Armin Labs, whose tests are known to overdiagnose people with Lyme (I have a memory from this forum that some very healthy journalist tried the test as an experiment once and it came back positive). A lot of people are told in alt med/Lyme circles that the...

Ala Taji Heravi ∙ Dmitry Gryaznov ∙ Jason W. Busse ∙ Christof Manuel Schönenberger ∙ Belinda von Niederhäuserne ∙ Lena Hausheer ∙ Manuela Covino ∙ Johannes M. Schwenke ∙ Selina Epp ∙ Alexandra Griessbach ∙ Malena Chiaborelli ∙ Arnav Agarwal ∙ Szimonetta Lohner ∙ Julian Hirt ∙ Stefan...

Paper suggested by @Yann04

Full title: Cardiovascular disease prevention and management in COVID-19: a clinical consensus statement of the European Association of Preventive Cardiology, the European Association of Cardiovascular Imaging, the Association of Cardiovascular Nursing & Allied Professions, the European...

Paper suggested by @Utsikt

Abstract Injected COVID-19 vaccines protect against severe disease, but do not induce robust mucosal immune responses. Nasal vaccines offer the advantage of local immunity to block viral infection and transmission. Previously we showed immunization of a Pam2Cys-adjuvanted SARS-CoV-2 vaccine to...

About mono/glandular fever: it is the same in Hungary. I never heard of it until I got mono myself in my early thirties (leading to my ME/CFS). I don't remember any high school/college kids I knew who had it. Whenever I tell my story, I need to explain to people what mono is, they don't know...

Paper suggested by @Yann04

ABSTRACT Background This study evaluated the impact of aging on the frequency and prevalent symptoms of Long COVID, also termed post-acute sequelae of SARS-CoV-2, using a previously developed Long COVID research index (LCRI) of 41 self-reported symptoms in which those with 12 or more points...

Paper suggested by @Utsikt

Abstract Foxp3+ regulatory T (Treg) cells, as one of the subtypes of CD4+ T cells, are the crucial gatekeeper in the pathogenesis of self-antigen reactive diseases. In this context, we demonstrated that the selective ablation of early growth response gene 1 (Egr-1) in CD4+ T cells exacerbated...