Both fibromyalgia and post viral fatigue syndrome have hundreds of multiple test corrected significant proteins. I haven't looked very closely at...
This is the UK biobank proteomics data, so it's the same dataset that Beentjes/Ponting et al biomarker preprint use. Same set of proteins it seems...
Link: https://www.cell.com/cell/fulltext/S0092-8674(24)01268-6 Highlights • Construct a comprehensive proteomics atlas for 1,706 human diseases...
Ah thank you, I missed that! I wonder how that might affect the cohort. If you're missing diagnoses from primary care are you looking at people...
I think wage is a very reasonable proxy for health, and it does seem like there is almost no one who has very low wages at diagnosis that go on to...
I know from the work you've done with the emea data that the main onset peak in that data is midlife as you say. Mecfs skeptic's graph looks to...
Very interesting thank you for your response! Lots I want to ask about that but I'll restrain myself (such as how Kupffer cells would get...
Just checked and my CRP levels have always been well under 1 mg/L, measured 3 or 4 times over the last decade. In the beentjes paper they report...
This is a good point. They have this plot showing the relationship of microclot counts with time since infection in the people who had covid but...
Really powerful article thankyou so much Chris and Simon. I'll be sharing this with my friends and family
For me the shakiest part of their argument is suggesting that PDH inhibition is the cause and that the increased respiratory capacity they see in...
I'm not sure, but isn't the question of regulation of amino acid use also linked to the question of why pyruvate dehydrogenase is inhibited in the...
Tronstadt's group do another metabolomics study in a 2021 paper, and don't really replicate their 2016 result in their whole ME cohort but do...
The muscle metabolomics done by Rob Wust's team in long covid would fit fairly well with that: [ATTACH] If glutamate and alpha-ketoglutarate are...
I'm quite pleased to see these changes. I would still prefer if the link text itself referred to mecfs rather than cfs, but the most important...
Moved posts I think there was a thread about this but I can't find it so posting here. I think the NHS website for ME/CFS has been improved....
The amino acid results in Tronstadt's 2016 paper seem to be pretty much a female only effect. Interesting! I don't know unfortunately, maybe...
So true! I can't imagine what would happen to me if I did a CPET. Must be dangerous for so many people. Maybe something like longitudinal sampling...
Good point about group 3. Group 2 generates acetyl CoA but group 3 don't so you would expect levels of oxaloacetate/ malate to increase and...
My concern with the amino acid findings in Tronstad 2016 is that it doesn't seem to replicate very well. Amino acid differences are not really...
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