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Seems he's retired - he's listed as emeritus professior here: https://www.trophoblast.cam.ac.uk/people/john-trowsdale Perhaps he or your old colleague might know who's still in the field working on this stuff who might be a good candidate?

As someone who had depression and intense 'anxiety' (DPDR, panic attacks, akathesia) since late teens, I see a lot of people on the long covid subreddit who have my pre full ME onset symptoms after a covid infection (including horrendous hangovers after drinking alcohol and cannabis...

From the main BTN2A2 thread- seems there might be some at Cambridge uni?

I have just seen I asked this a month and a half ago. Earlier I went on the BTN2A2 thread to ask if there were any experts in that we could get involved in research and found I'd asked that last month:banghead: MECFS brain fog is kind of funny, kind of scary.

Just been rereading this thread - is it likely they will publish preliminary results? I thought they wanted to keep the blinding for 72 weeks? I suppose they could unblind the clinicians and not the patients initially - is that ever done?

Anyone know if we're likely to see the James PET tracer paper before the Charite conference?

How can the lay public sort it out? It's funny, so many people have horrendous stories of mistreatment by doctors but they still want to believe there is nothing wrong with the system these doctors belong to.

Ten years is an insanely long time. PwME, especially severe, die all the time sadly. Just this week there have been something like 4 deaths reported. Why can't they do this faster considering how important this finding seems? I think we need better systems for posthumous donation for pwME. I...

Do you know if this was the same for the other drugs they tested?

A concerning thought. I've just checked and apparently microglia can regenerate so hopefully this is potentially reversible if it's true. https://pmc.ncbi.nlm.nih.gov/articles/PMC5540680/ However it says they renew at 28% per year so if this were the cause of severe MECFS it wouldn't account...

That's a little concerning...

Which other studies have found upregulated FOXP3? I know they exist but can't find them on here or remember which they were.

I knew I'd seen galectin-9 somewhere before! This lot seem like pretty serious researchers. Interesting that they found dysregulated B cell and platelet signatures and FOXP3 upregulation in vanilla MECFS. What does this actually mean though? the parts about activation and exhaustion are vague...

Excellent news, thank you. Do you know what potential biomarkers they are looking at?

There is evidence that people with MECFS sometimes improve a little or a lot. It is not the norm but it is common enough, especially early on. This is probably why so many people think they recovered from brain retraining and stuff. The odds of 6/10 patient with MECFS as we understand it...

So there's no mention of how many patients they studied in this abstract. Is this a valid method of comparison? Comparing fresh blood against a database in this way? Edit: I really dislike how they use 'idiopathic MECFS' here. Reminds me too much of the BPS 'idiopathic chronic fatigue'...

I believe at some point in a presentation or lecture he gave Afrin claimed MCAS can cause spontaneous human combustion.

Agree with what you're saying, but I think the fact it is Fluge and Mella who ran this trial as opposed to say, the US recover program makes it more likely that they carefully selected patients representative of most pwME as we are familiar with them.

This is interesting, especially the interferon part. @jnmaciuch would reducing type I interferon resolve the kind of mechinism/signalling loop you have proposed in ME/CFS?