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    CoQ10 - Coenzyme Q10

    Interesting new study connecting coq10, glutathione and methylation Coenzyme Q10 modulates sulfide metabolism and links the mitochondrial respiratory chain to pathways associated to one carbon metabolism (Gonzalez-Garcia, 2020)
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    The biology of coronavirus COVID-19 - including research and treatments

    I think we don't know if ACE inhibitors increase or decrease infection/severity yet. As far as I understand(I may be wrong), he is saying that IFNy and IFNa do increase risk. That's why I'm wondering if we have elevated levels or not.
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    The biology of coronavirus COVID-19 - including research and treatments

    Do we have reliable evidence showing that IFNs are elevsted in ME?
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    Gut DNA Virome Diversity and Its Association with Host Bacteria Regulate Inflammatory Phenotype and Neuronal Immunotoxicity... (Seth, 2019)

    You have to start somewhere, don't you?
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    Gut DNA Virome Diversity and Its Association with Host Bacteria Regulate Inflammatory Phenotype and Neuronal Immunotoxicity... (Seth, 2019)

    Open access: https://www.mdpi.com/1999-4915/11/10/968
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    New Scientist: Humans are cooling down so average body temperaturs is no longer 37 C

    0.03 per decade. There are 20 decades in 200 years. 0.03*20=0.6°
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    Efficacy of faecal microbiota transplantation for patients with [IBS] in a randomised, double-blind, placebo-controlled study, 2019, El-Salhy et al

    23% vs 89%?? Wow. Some good shit they have there..
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    Researcher Interactions Video: Science for ME Q&A with Dr Michael VanElzakker, Oct 2019

    Great stuff. I think he's right that we should pull back a little and think more about the mechanisms.
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    Differentiating Psychosomatic, Somatopsychic, Multisystem Illnesses and Medical Uncertainty, 2019, Bransfield, Friedman

    Merged thread A bit too opmtimistic, IMO: https://www.mdpi.com/2227-9032/7/4/114/htm
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    3rd Annual Community Symposium on the Molecular Basis of ME/CFS at Stanford University, sponsored by OMF, 7th Sept 2019

    I took black seed oil and, like most of the things, it made me worse.
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    News from Germany

    Definitely worse. We literally have nothing. I was lucky that one doctor told me that I probably have 'CFS' and it's not a psychiatric disease, but at the same time, was also told that psychiatrists usually 'take care' of these patients, which basically means that psychiatrists are very happy to...
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    Michael Sharpe: Mind, Medicine and Morals: A Tale of Two Illnesses (2019) BMJ blog - and published responses

    Not CFS, but still relevant:
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    A nanoelectronics-blood-based diagnostic biomarker for ME/CFS (2019) Esfandyarpour, Davis et al

    The problem with SW comment is not the actual words, but the context and the the underlying meaning which are not obvious to the average reader. A person has to really lack any self awareness to make that comment (It is also regrettable that it is claimed that such a test would give “scientific...
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    A nanoelectronics-blood-based diagnostic biomarker for ME/CFS (2019) Esfandyarpour, Davis et al

    Hmm... Tens of thousands?? Let's be reasonable. Nothing even close to that would be needed. I don't think so. He's a high level scientist and likely doesn't want to throw around phrases which do not necessarily have much to do with reality (encephalitis). Clearly Wessely still believes in his...
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    "Answer to IBS is in the mind" - media coverage of new Chalder/Moss-Morris trial

    We've seen this somewhere, haven't we?
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    A Timely Multidisciplinary Update on ME/CFS, 2019, Theoharides

    I got the same impression from the Q&A of the last year's IIME conference. I believe he asked some weird/basic question, which seemed odd to me. As for the conclusion, it all goes back to his theory that it all relates to mast cells, and that the problem lies in the brain, which I think is...
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    Protocol Faecal microbiota transplantation (FMT) in Norwegian outpatients with mild to severe ME/CFS: protocol (...), 2024, Skjevling et al. Comeback Study

    I'm a bit worried that they've decided to use enema instead of colonoscope for the transplant. Somehow this doesn't seem to be an optimal way to deliver the bacteria to the whole colon.
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    Epigenetic Components of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Uncover Potential Transposable Element Activation (Almenar-Pérez 2019)

    I won't even pretend to understand what this paper really is about, but looks interesting.
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    Epigenetic Components of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Uncover Potential Transposable Element Activation (Almenar-Pérez 2019)

    EloyAlmenar-PérezMSc TamaraOvejeroPhD TeresaSánchez-FitoMSc José A.EspejoBSc LubovNathansonPhD ElisaOltraPhD Abstract: FULL: https://sci-hub.tw/10.1016/j.clinthera.2019.02.012 https://www.sciencedirect.com/science/article/abs/pii/S0149291819300724
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    30th Nov: Cochrane 'have not approved publication of the [Larun] re‐submission' - but old version not withdrawn either.

    Can you really 'update' a sinking ship?
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