allodynia

Chronic stress primes TLR3-mediated systemic inflammation to produce persistent post-viral fatigue syndrome-like symptoms in mice Highlights • Chronic stress in combination with poly I:C produces persistent multi-domain PVFS-like symptoms in mice. • Minocycline attenuates fatigue...

Abstract Allodynia (perceiving touch as painful) is an enduring symptom of neuropathic pain. While acute pain is initiated by afferent signaling from the periphery to spinal cord, pain chronification recruits ongoing activity in supraspinal sites. One such site that has been proposed to be...

Until a few days ago, I did not know this award existed. I found this description of the co-winners of the prize. work to be interesting and a worthwhile read. This is one area where mouse models have contributed towards advancing the understanding of the human physiology. The complexity of...

I am still reading this… this is a very good summary by some leading researchers about the difficulties they have encountered in trying to develop non-opioid painkillers using the sodium channel Nav1.8. It’s been a difficult and perplexing process and there’s an immense amount of pressure to...

Spinal cord microglia drive sex differences in ethanol-mediated PGE2-induced allodynia Alexander; Reed; Burton The mechanisms of how long-term alcohol use can lead to persistent pain pathology are unclear. Understanding how earlier events of short-term alcohol use can lower the threshold of...

Apparently, significant research in the field of allodynia. Here is a nice write up about the study, including comments by some prominent researchers in the field. https://www.painresearchforum.org/news/126263-pain-nerve-endings-“bare”-no-more here is the study abstract...

Am posting this because it is common among people with Fibromyalgia, ME, CFS and those who suffer from migraines but not everyone knows it is a diagnosable condition. " Allodynia is pain, generally on the skin, caused by something that wouldn't normally cause pain. This pain type is associated...