ampa

Wake-active brainstem GABA neurons signal sleep pressure by upregulating AMPA receptors to drive recovery sleep How the brain compensates for sleep deprivation (SD) by generating recovery sleep (RS) is not understood. Using Ca²⁺ photometry, we identified a WAKE/rapid eye movement sleep...

Biological Insights from Genome-Wide Association Studies and Whole Genome Sequencing of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Maccallini, Paolo Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disorder of poorly understood etiology. We...

Neuronal ARHGAP8 controls synapse structure and AMPA receptor-mediated synaptic transmission The aberrant formation and function of neuronal synapses are recognized as major phenotypes in many cases of neurodevelopmental (NDDs) and -psychiatric disorders (NPDs). A growing body of research has...

Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity Trafficking and biophysical properties of AMPA receptors (AMPARs) in the brain depend on interactions with associated proteins. We identify Shisa6, a single transmembrane protein, as a...

The locus near SHISA6 wasn't quite genome-wide significant, but it was close at p=8.26e-08. From GeneCards: Here is a plot of this locus (LocusZoom link): Edit: The lead variant at this locus is: 17:11,325,637:G:C / rs1546559

Dynamic extracellular interactions with AMPA receptors Synaptic plasticity in the central nervous system enables the encoding, storing, and integrating new information. AMPA (alpha-amino-3-hydroxyl-5-methyl-isoxazole-4-propionic acid)-type glutamate receptors (AMPARs) are ligand-gated ion...

AMPA receptors in the synapse: Very little space and even less time Jelena Baranovic Glutamate is by far the most abundant neurotransmitter used by excitatory synapses in the vertebrate central nervous system. Once released into the synaptic cleft, it depolarises the postsynaptic membrane and...

Systemic increase of AMPA receptors associated with cognitive impairment of long COVID Long COVID primarily presents with persistent cognitive impairment (Cog-LC), imposing a substantial and lasting global burden. Even after the pandemic, there remains a critical global need for diagnostic and...

New insights into how glutamate opens brain cell signaling channels eta: Journal reference: Mondal, A. K., et al. (2025). Glutamate gating of AMPA-subtype iGluRs at physiological temperatures. Nature. doi.org/10.1038/s41586-025-08770-0.

Neocortex saves energy by reducing coding precision during food scarcity Zahid Padamsey, Danai Katsanevaki, Nathalie Dupuy, Nathalie L Rochefort Abstract Information processing is energetically expensive. In the mammalian brain, it is unclear how information coding and energy use are regulated...