atf4

  1. SNT Gatchaman

    Review Type I interferons and endoplasmic reticulum stress in health and disease, 2020, Sprooten and Garg

    Type I interferons and endoplasmic reticulum stress in health and disease Sprooten; Garg Type I interferons (IFNs) comprise of pro-inflammatory cytokines created, as well as sensed, by all nucleated cells with the main objective of blocking pathogens-driven infections. Owing to this broad range...
  2. SNT Gatchaman

    Specific activation of the integrated stress response uncovers regulation of central carbon metabolism and lipid droplet biogenesis, 2024, Labbé et al

    Specific activation of the integrated stress response uncovers regulation of central carbon metabolism and lipid droplet biogenesis Labbé, Katherine; LeBon, Lauren; King, Bryan; Vu, Ngoc; Stoops, Emily H.; Ly, Nina; Lefebvre, Austin E. Y. T.; Seitzer, Phillip; Krishnan, Swathi; Heo, Jin-Mi...
  3. SNT Gatchaman

    SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication, 2023, Montezano et al.

    SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication Montezano, Augusto C.; Camargo, Livia L.; Mary, Sheon; Neves, Karla B; Rios, Francisco J; Stein, Ross; Lopes, Rheure A.; Beattie, Wendy; Thomson, Jacqueline; Herder, Vanessa; Szemiel, Agnieszka...
  4. SNT Gatchaman

    A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy, 2023, Southwell et al.

    A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy Nneka Southwell; Guido Primiano; Viraj Nadkarni; Nabeel Attarwala; Emelie Beattie; Dawson Miller; Sumaitaah Alam; Irene Liparulo; Yevgeniya I Shurubor; Maria Lucia Valentino; Valerio Carelli; Serenella...
    • SNT Gatchaman
    • Thread
    • amino acids atf4 fatty acid metabolism fatty acid oxidation fgf21 gdf15 integrated stress response lipid droplets lipid metabolism lipids metabolism mitochondria mtor muscle myopathy tca cycle
    • Replies: 4
    • Forum: Other health news and research
  5. J

    GDF15 linked to maternal risk of nausea and vomiting during pregnancy 2023 Fejzo et al (hyperemesis gravidarum - morning sickness in pregnancy)

    https://www.nytimes.com/2023/03/14/well/marlena-fejzo-hyperemesis-gravidarum.html?unlocked_article_code=i7exBjGLMkMQVJKOgEZ_PBv29j4GYrj4q6R0YqeSGQumAtqyVKkXwLaZ7KLVZGykBQcxBasbEjYPcILSMlSxNDlw_xrprtr7hB0f7w_NpdqRTRX0ASFJqoJE3nbD1s1ehkYpzQPzcFMspQHlhOMLG0wwGtq1IVxqeaiDdNQ3_Of5T64T45gIEO70aUzvW5kwN...
  6. D

    Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR

    https://advances.sciencemag.org/content/7/22/eabf0971/tab-article-info https://doi.org/10.1126/sciadv.abf0971 Abstract In response to disturbed mitochondrial gene expression and protein synthesis, an adaptive transcriptional response sharing a signature of the integrated stress response (ISR)...
  7. MyalgicE

    Mitochondrial stress causes neuronal dysfunction via an ATF4-dependent increase in L-2-hydroxyglutarate (2019) Hunt et al

    Abstract Mitochondrial stress contributes to a range of neurological diseases. Mitonuclear signaling pathways triggered by mitochondrial stress remodel cellular physiology and metabolism. How these signaling mechanisms contribute to neuronal dysfunction and disease is poorly understood. We find...
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