coq10

Full title: Exploring the neuroprotective role of ubiquinone by attenuation of oxidative stress and mitochondrial dysfunction in an experimental model of myalgic encephalomyelitis/chronic fatigue stress In exhausted mice. Abstract Background Myalgic encephalomyelitis (ME) or chronic fatigue...

https://www.researchsquare.com/article/rs-5362194/v1 Adverse effects of CoenzymeQ10 in the treatment of patients with chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS) Gunnar L. Olsson1 1 Karolinska Institute Purpose In an ongoing study of oxidative stress and the effect of...

Abstract Background Contracting skeletal muscle produces reactive oxygen species (ROS) originating from both mitochondrial and cytosolic sources. The use of non-specific antioxidants, such as vitamins C and E, during exercise has produced inconsistent results in terms of exercise performance...

This discusses CoQ10 deficiency disorder. I'm posting because it mentions exercise intolerance and cognitive dysfunction as symptoms multiple times, as well as because CoQ10 is an oft mentioned supplement in the ME/CFS world. Abstract Background: Primary deficiency of coenzyme Q10 deficiency-4...

Full title: Coenzyme Q deficiency in endothelial mitochondria caused by hypoxia; remodeling of the respiratory chain and sensitivity to anoxia/reoxygenation Highlights In endothelial cells, hypoxia reduces HMGCR levels via HIF1α, leading to Q deficiency. The hypoxia-induced increased level...

https://direct.mit.edu/neco/article-abstract/26/11/2594/7999/Coenzyme-Q10-Benefits-Symptoms-in-Gulf-War?redirectedFrom=fulltext paywall I think Abstract We sought to assess whether coenzyme Q10 (CoQ10) benefits the chronic multisymptom problems that affect one-quarter to one-third of 1990–1...

Multiple System Atrophy: -slowness of movement, tremor, or stiffness -clumsiness or lack of coordination -impaired speech -croaky quivering voice -fainting or lightheadedness due to orthostatic hypotension Summary Background Functionally impaired variants of COQ2, encoding an enzyme in...

Preprint and final publication threads merged Final publication abstract further down the thread here Abstract Background: Post COVID-19 condition (PCC) is defined as symptoms lasting more than 12 weeks after developing COVID-19. Evidence of mitochondrial dysfunction has been reported in...

Abstract: Chronic COVID syndrome is characterized by chronic fatigue, myalgia, depression and sleep disturbances, similar to chronic fatigue syndrome (CFS) and fibromyalgia syndrome. Implementations of mitochondrial nutrients (MNs) with diet are important for the clinical effects antioxidant...

Full title: Does Dietary Coenzyme Q10 plus Selenium Supplementation Ameliorate Clinical Outcomes by Modulating Oxidative Stress and Inflammation in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome? Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a...

Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial Castro-Marrero et al Abstract Myalgic...

The human body, particularly the brain, requires energy, stored in the form of adenosine triphosphate. Energy metabolism during cellular respiration is dependent on the presence of multiple micronutrients, which act as essential components, coenzymes, or precursors at every stage. An adequate...

Abstract Coenzyme Q10 (CoQ10) is an essential cofactor in oxidative phosphorylation (OXPHOS), present in mitochondria and cell membranes in reduced and oxidized forms. Acting as an energy transfer molecule, it occurs in particularly high levels in the liver, heart, and kidneys. CoQ10 is also an...

Review article: Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: a possible approach to SARS-CoV-2 ‘long-haulers’? EmilyWood, Katherine H.Hall, WarrenTate (University of Otago, New Zealand)...

I'm writing an article on CoQ10 and MitoQ for my local group's newsletter; these supplements are often recommended by both people with ME/CFS and clinicians. We don't seem to have a thread specifically on this yet. I'm interested in the evidence for CoQ10 supplementation being helpful for...

https://scienmag.com/three-papers-help-to-crack-the-code-of-coenzyme-q-biosynthesis/