cpet

Symptom burden, lung function, exercise tolerance and inflammation in patients post COVID-19: results from the prospective COVID-19 Chronic Morbidity CCHROMO study BACKGROUND Post-COVID syndrome is common and associated with substantial morbidity, yet its pathophysiology and predictors of...

Safety of Cardiopulmonary Exercise Testing in Patients with Severe Post- COVID-19 Condition: A Matched Case- Control Study Abstract Patients severely affected by post-COVID-19 condition (PCC) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) exhibit reduced physical capacity...

Cardiopulmonary Exercise Testing Reveals Functional Limitations and Work Disability in Severe Post-COVID-19 and ME/CFS Patients Background Patients severely affected by post-COVID-19 condition (PCC) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) often experience long-term...

Abstract Long COVID (LC) is a multisystem condition that is linked to distinct pathologies including viral persistence, immunological dysfunction, endothelial damage, and mitochondrial dysfunction. To date, limited research has assessed peripheral tissue hypoxia to better understand LC symptom...

Cardiopulmonary Exercise Test Results Do Not Change Over Two Sequential Days in Patients with Chronic Fatigue Syndrome Background Two consecutive cardiopulmonary exercise tests (CPETs) performed 24 hours apart is increasingly used to determine post-exertional malaise (PEM) and disability in...

Assessment of physical status and analysis of lipidomic and metabolomic alterations in patients with Post-COVID-19 condition The development and persistence of symptoms following SARS-CoV-2 infection, known as Post-COVID-19 Condition (PCC) or “long COVID,” represents a global health challenge...

Shared autonomic phenotype of long COVID and myalgic encephalomyelitis/chronic fatigue syndrome Peter Novak; David M Systrom; Alexandra Witte; Sadie P Marciano; Donna Felsenstein; Jeff M Milunsky; Aubrey Milunsky; Joel Krier; Mark C Fishman INTRODUCTION Long COVID and myalgic...

ME/CFS and Long COVID Demonstrate Similar Bioenergetic Impairment and Recovery Failure on Two-Day Cardiopulmonary Exercise Testing Todd Davenport; Staci Stevens; Jared Stevens; Mark Van Ness Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long Covid are characterized by...

Symptomatic post COVID patients have impaired alveolar capillary membrane function and high VE/VCO2 BACKGROUND Post COVID-19 syndrome is characterized by several cardiorespiratory symptoms but the origin of patients reported symptomatology is still unclear. METHODS Consecutive post COVID-19...

Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: a case–control study BACKGROUND Chronic fatigue syndrome (CFS) patients frequently describe difficulties with repeat exercise. Here, we explore muscle bioenergetic function in response to three bouts of...

Donna M. Mancini, Danielle L. Brunjes, Dane Cook, Tiffany Soto, Michelle Blate, Patrick Quan, Tadahiro Yamazaki, Anna Norweg, Benjamin H. Natelson Abstract Introduction: Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) experience symptoms of fatigue, dyspnea, mental...

New CPET Guidelines: What They Mean for People with ME/CFS The American College of Sports Medicine’s Guidelines for Exercise Testing and Prescription, for the first time, includes a section on ME/CFS. ACSM is a leading authority on exercise science, and these guidelines serve as a foundational...

Abstract Post-exertional malaise (PEM) is a defining symptom of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), yet its molecular underpinnings remain elusive. This study investigated the temporal–longitudinal DNA methylation changes associated with PEM using a structured two-day...

A Novel FiO2 Titration Protocol for Quantifying Pulmonary Oxygen Reserve Capacity : Dynamic Assessment Framework for Infection-Associated Respiratory Dysfunction Abstract Background Progressive decline in pulmonary oxygen reserve capacity (ORC) is a hallmark of infection-associated respiratory...

Design and validation of an energy level diary for fatigue management in patients with post-COVID syndrome BACKGROUND Post-COVID syndrome (PCS) is a frequent condition with an incidence of 7.8–10.6 per 100 unvaccinated and 3.5–5.3 events per 100 vaccinated persons. Cognitive and motor fatigue...

Characterising dysfunctional breathing seen in post-acute sequelae of SARS-CoV-2 using approximate entropy Erin Eschbach; Benjamin H. Natelson; Donna M. Mancini; Dane B. Cook; Kevin Rurak; Melissa Miranda; Beno W. Oppenheimer; David M. Rapoport; Ankit Parekh RATIONALE Dysfunctional breathing...

Preload insufficiency as common denominator of exertional dyspnoea in distinct post-COVID phenotypes G Oruqaj; K Lo; K Krüger; P Bauer; L Laufer; K Milger; C Tabeling; I Pink; Z Rako; N Kremer; S Yildiz; J Behr; M Hecker; M Kaya; S Kuhnert; HH Krämer-Best; U Matt; S Herold; S Oberwinkler; J...

Sympathetic Neural Overdrive, Vascular Dysfunction and Diminished Exercise Capacity in Long COVID-19 Patients: A Long-Term Study of Cardiovascular Sequelae Bruna E. Ono; João E. Izaias; Artur O. Sales; Thais S. Rodrigues; Camila S. Nunes; Jessica F. Niec; Natalia G. Rocha; Helena N.M. Rocha...

https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1534352/abstract Background: Post-exertional malaise (PEM) is a central feature of Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and has emerged as a prominent feature of Long COVID. The optimal clinical...

Wearable heart rate variability monitoring identifies autonomic dysfunction and thresholds for post-exertional malaise in Long COVID Twan Ruijgt, Anouk Slaghekke, Anneke Ellens, Kasper Janssen, Rob CI Wust Objectives Patients with Long COVID experience disabling fatigue, autonomic dysfunction...