ddhd2

Neurons run on fat Neurons were long thought to depend primarily on glucose metabolism for ATP production. However, recent findings from three laboratories show neurons metabolise long-chain fatty acids as alternative fuel. Here, we highlight emerging evidence on the neutral lipid lipase DDHD2...

Abstract Proper fuelling of the brain is critical to sustain cognitive function, but the role of fatty acid (FA) combustion in this process has been elusive. Here we show that acute block of a neuron-specific triglyceride lipase, DDHD2 (a genetic driver of complex hereditary spastic paraplegia)...