endothelial cells

IgA autoimmunity and coagulation among post-acute sequelae of SARS-CoV-2 infection (PASC) patients with persistent respiratory symptoms: a case-control study Claudia Gomes, Jonathan H. Whiteson, Fabio Ponzo, Rany Condos, Mila B. Ortigoza, Marisol Zuniga, Ana Rodriguez, David C. Lee [Line...

Virus-Induced Endothelial Senescence as a Cause and Driving Factor for ME/CFS and Long COVID: Mediated by a Dysfunctional Immune System Massimo Nunes, Loren Kell, Anouk Slaghekke, Rob Wüst, Burtram Fielding, Douglas Kell, Etheresia Pretorius Abstract Myalgic encephalomyelitis/chronic fatigue...

Sympathetic Neural Overdrive, Vascular Dysfunction and Diminished Exercise Capacity in Long COVID-19 Patients: A Long-Term Study of Cardiovascular Sequelae Bruna E. Ono; João E. Izaias; Artur O. Sales; Thais S. Rodrigues; Camila S. Nunes; Jessica F. Niec; Natalia G. Rocha; Helena N.M. Rocha...

Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19 Felix Röttele; Andreas Zollner; Carolin Mogler; Muhammed Yuksel; Cigdem Arikan; Vivien Karl; Judith Helene Aberle; Stephan...

CircSARS-CV2-N1368 from SARS-CoV-2 impairs endothelial cell function through the upregulation of ATF7 to activate TLR4/NF-κB/ROS signaling Wen, Yi-hong; Zhao, Heng-li; Wu, Shao-yu; Jiang, Jia-xue; Gao, Yuan; Wang, Zi-fan; Liu, Xiao-yao; Yu, Fei; Ou, Tao; Zhao, An-zhi; Chen, Li-wen; Fang...

Sustained Vascular Inflammatory Effects of SARS-CoV-2 Spike Protein on Human Endothelial Cells Gultom, Mitra; Lin, Lin; Brandt, Camilla Blunk; Milusev, Anastasia; Despont, Alain; Shaw, Jane; Döring, Yvonne; Luo, Yonglun; Rieben, Robert Severe acute respiratory syndrome coronavirus 2...

Astrocytic mitochondrial transfer to brain endothelial cells and pericytes in vivo increases with aging Gopal V Velmurugan; Hemendra J Vekaria; Samir P Patel; Patrick G Sullivan; W Brad Hubbard Intercellular mitochondrial transfer (IMT) is an intriguing biological phenomenon where mitochondria...

Maternal COVID-19 infection associated with offspring neurodevelopmental disorders Duan, Lian; Yin, Huamin; Liu, Jiaxin; Wang, Wenhang; Huang, Peijun; Liu, Li; Shen, Jingling; Wang, Zhendong Maternal COVID-19 infection increases the incidence of neurodevelopmental disorders (NDDs) in offspring...

Abstract Evidence linking the endothelium to cardiac injury in long coronavirus disease (COVID) is well documented, but the underlying mechanisms remain unknown. Here we show that cytokines released by endothelial cells (ECs) contribute to long-COVID-associated cardiac dysfunction. Using...

Impaired instructive and protective barrier functions of the endothelial cell glycocalyx pericellular matrix is impacted in COVID-19 disease M. Smith Margaret; James Melrose The aim of this study was to review the roles of endothelial cells in normal tissue function and to show how COVID-19...

Targeting the High-Density Lipoprotein Proteome for the Treatment of Post-Acute Sequelae of SARS-CoV-2 Grote, Karsten; Schaefer, Ann-Christin; Soufi, Muhidien; Ruppert, Volker; Linne, Uwe; Mukund Bhagwat, Aditya; Szymanski, Witold; Graumann, Johannes; Gercke, Yana; Aldudak, Sümeya...

Mast cell activation triggered by SARS-CoV-2 causes inflammation in brain microvascular endothelial cells and microglia Wu, Meng-Li; Xie, Chengzuo; Li, Xin; Sun, Jing; Zhao, Jincun; Wang, Jian-Hua SARS-CoV-2-induced excessive inflammation in brain leads to damage of blood-brain barrier...

The S1 subunits of SARS-CoV-2 variants differentially trigger the IL-6 signaling pathway in human brain endothelial cells and downstream impact on microglia activation Michael Stangis; Daniel Adesse; Bhavya Sharma; Eduardo Castro; Kush Kumar; Neil Kumar; Masha Minevich; Michal Toborek...

COVID-19 and Long COVID: Disruption of the Neurovascular Unit, Blood-Brain Barrier, and Tight Junctions Duraisamy Kempuraj; Kristina K. Aenlle; Jessica Cohen; Annette Mathew; Dylan Isler; Rajendra P. Pangeni; Lubov Nathanson; Theoharis C. Theoharides; Nancy G. Klimas Severe acute respiratory...

Diminished vasculogenesis under inflammatory conditions is mediated by Activin A Manohar-Sindhu, Sahana; Merfeld-Clauss, Stephanie; Goddard, Yana; March, Keith L.; Traktuev, Dmitry O. Severe inflammatory stress often leads to vessel rarefaction and fibrosis, resulting in limited tissue...

Proinflammatory Mediators, IL Interleukin-1β, TNF Tumor Necrosis Factor α, and Thrombin Directly Induce Capillary Tube Regression Gretchen M. Koller; Christopher Schafer; Scott S. Kemp; Kalia N. Aguera; Prisca K. Lin; Joshua C. Forgy; Courtney T. Griffin; George E. Davis OBJECTIVE: In this...

SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells Yang, Kai; Liu, Shiyun; Yan, Han; Lu, Wenju; Shan, Xiaoqian; Chen, Haixia; Bao, Changlei; Feng, Huazhuo; Liao, Jing; Liang, Shuxin; Xu, Lei; Tang...

Abstract Ebola virus (EBOV) causes severe hemorrhagic fever in humans with high mortality. In Ebola virus disease (EVD) survivors, EBOV persistence in the eyes may break through the inner blood–retinal barrier (iBRB), leading to ocular complications and EVD recurrence. However, the mechanism by...

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction Fuyuko Takata, Shinsuke Nakagawa, Junichi Matsumoto, Shinya Dohgu Neuroinflammation is...

Abstract Trimethylamine N-oxide (TMAO) is a diet derived compound directly introduced through foodstuff, or endogenously synthesized from its precursors, primarily choline, L-carnitine, and ergothioneine. New evidence outlines high TMAO plasma concentrations in patients with overt...