exercise intolerance

Sympathetic Neural Overdrive, Vascular Dysfunction and Diminished Exercise Capacity in Long COVID-19 Patients: A Long-Term Study of Cardiovascular Sequelae Bruna E. Ono; João E. Izaias; Artur O. Sales; Thais S. Rodrigues; Camila S. Nunes; Jessica F. Niec; Natalia G. Rocha; Helena N.M. Rocha...

The effect of COVID-19 on cardiovascular function and exercise tolerance in healthy middle-age and older individuals Sophie L. Russell; Nduka C. Okwose; Mushidur Rahman; Ben J Lee; Gordon McGregor; Stuart M. Raleigh; Hardip Sandhu; Laura C. Roden; Prithwish Banerjee; Djordje G. Jakovljevic AIMS...

Abstract: Rare defects in the promoter region of SLC16A1,the gene encoding monocarboxylate transporter 1 (MCT-1), result in exercise-induced hyperinsulinism. In this disorder inappropriate insulin secretion is triggered by anaerobic exercise with consequent hypoglycaemia. We describe the case...

Abstract Background: Postural Orthostatic Tachycardia Syndrome (POTS) is a syndrome of an exaggerated heart rate (HR) response with standing, disproportionately affecting young women associated with exercise intolerance due to dizziness, palpitations, and/or chest pain. Research question: How...

Abstract: Acute infections are associated with multiple host responses that are triggered by cytokines and correlated to fever, malaise and anorexia. The purpose of this systemic acute phase host reaction („the acute phase response”) is to mobilize nutrients for the increased needs of the...

Abstract: Exertional fatigue, defined as the overwhelming and debilitating sense of sustained exhaustion that impacts the ability to perform activities of daily living, is highly prevalent in chronic kidney disease (CKD) and end-stage renal disease (ESRD). Subjective reports of exertional...

I thought It would be interesting to have a place to collect descriptions or accounts of living with other illnesses that include phenomena seemingly nearly identical to what we call PEM. For Mitochondrial disease, check out the thread: What differentiates ME/CFS from known primary...

Adrenergic dysfunction in patients with myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia: A systematic review and meta-analysis Jolien Hendrix; Lara Fanning; Arne Wyns; Ishtiaq Ahmed; Madhura Shekhar Patil; Emma Richter; Jente Van Campenhout; Kelly Ickmans; Rembert Mertens; Jo...

Exercise Intolerance Is Associated with Cardiovascular Dysfunction in Long COVID-19 Syndrome Vontetsianos, Angelos; Chynkiamis, Nikolaos; Gounaridi, Maria Ioanna; Anagnostopoulou, Christina; Lekka, Christiana; Zaneli, Stavroula; Anagnostopoulos, Nektarios; Oikonomou, Evangelos; Vavuranakis...

This discusses CoQ10 deficiency disorder. I'm posting because it mentions exercise intolerance and cognitive dysfunction as symptoms multiple times, as well as because CoQ10 is an oft mentioned supplement in the ME/CFS world. Abstract Background: Primary deficiency of coenzyme Q10 deficiency-4...

Exercise does not cause post-exertional malaise in Veterans with Gulf War Illness: A randomized, controlled, dose–response, crossover study Boruch; Barhorst; Rayne; Roberge; Brukardt; Leitel; Coe; Fleshner; Falvo; Cook; Lindheimer ABSTRACT Chronic multisymptom illnesses (CMI) such as Myalgic...

Metabolic Disorders Causing Fatigue in Sjogren’s Syndrome ABSTRACT NUMBER: 2546 Metabolic Disorders Causing Fatigue in Sjogren’s Syndrome Lakshmanan Suresh1, Julian Ambrus2, Long Shen3 and Sahana Vishwanath4, 160 Pineview Drive, State University of New York/Buffalo, Buffalo, NY, 2100 High St...

Decreased Self-reported Physical Fitness Following SARS-CoV-2 Infection and the Impact of Vaccine Boosters in a Cohort Study Richard, Stephanie and 187 co-authors Background The long-term effects of coronavirus disease 2019 (COVID-19) on physical fitness are unclear, and the impact of...

Post-Vaccination Syndrome: A Descriptive Analysis of Reported Symptoms and Patient Experiences After Covid-19 Immunization Harlan M Krumholz; Yilun Wu; Mitsuaki Sawano; Rishi Shah; Tianna Zhou; Adith S Arun; Pavan Khosla; Shayaan Kaleem; Anushree Vashist; Bornali Bhattacharjee; Qinglan Ding...

Post-Acute Sequelae of SARS-CoV-2: More Than Deconditioning Phillip Joseph; Inderjit Singh No abstract. Link | PDF (CHEST)

Abstract Essential elements of Myalgic Encephalomyelitis (ME) are muscle (weakness) and tenderness, cognitive deficits, neurological impairments, especially of cognitive, autonomic and sensory functions, but above all, post-exertional “malaise”: a prolonged increase of symptoms after a minor...

The pre-publication thread has been merged with the thread on the paper. Link to paper's abstract here...

Associations between symptoms and functional capacity in patients after COVID-19 infection and community controls Quan Huynh; Noah Wexler; Joel Smith; Leah Wright; Felicia Ho; Richard Allwood; Yusuke Sata; Stefano Manca; Erin Howden; Thomas H. Marwick Background: Post-acute sequelae of COVID-19...

The Intriguing Role of Histamine in Exercise Responses 2017 Luttrell and Halliwill Brief Abstract In humans, histamine is a molecular transducer of physical activity responses, and antihistamines modify more than 25% of the genes responding to exercise. Although the upstream signal that results...

Highlights Ours is one of the first CPET studies to highlight reduced O2 pulse peak % predicted (impaired oxygen extraction) as a mechanism of chronic fatigue and exercise intolerance in long COVID. Our study identified chronotropic intolerance as a potential biomarker in long COVID. We...