glutamatergic synapses

Alcohol-driven AMPA receptor dysregulation across the lifespan Alcohol use produces persistent alterations in glutamatergic signaling that evolve across the lifespan, with α-amino-3‑hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) emerging as major contributors to these...

https://gut.bmj.com/content/early/2026/07/01/gutjnl-2026-338800 PDF Neurogastroenterology Original research Cross-definition GWAS of IBS in 2.8 million individuals reveals cardiometabolic and triglyceride-linked mechanisms Abstract Background Irritable bowel syndrome (IBS) is a complex...

Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry Anxiety is heritable and exists on a continuum, with symptoms ranging from adaptive threat response to clinical disorder. Here we performed a genome-wide association...

Wake-active brainstem GABA neurons signal sleep pressure by upregulating AMPA receptors to drive recovery sleep How the brain compensates for sleep deprivation (SD) by generating recovery sleep (RS) is not understood. Using Ca²⁺ photometry, we identified a WAKE/rapid eye movement sleep...

Hidden in the white matter: Current views on interstitial white matter neurons Maximilian Fischer; Maria Kukley The mammalian brain comprises two structurally and functionally distinct compartments: the gray matter (GM) and the white matter (WM). In humans, the WM constitutes approximately half...

Biological Insights from Genome-Wide Association Studies and Whole Genome Sequencing of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Maccallini, Paolo Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disorder of poorly understood etiology. We...