Identification of new overlapping and disease-specific genetic risk factors for rheumatoid arthritis and radiographic axial spondyloarthritis: a meta-analysis of three large European populations and functional characterization
Abstract
This study conducted a meta-analysis across three large...
Dysfunction of Primary Cilium in Huntington’s Disease: How Mutant Huntingtin Disrupts This Cellular Signaling Hub
Churkina, Aleksandra S; Shakhov, Anton S; Alieva, Irina B
Primary cilia are solitary, antenna-like organelles that project from the surface of most vertebrate cells. They consist of...
From DecodeME Candidate Genes:
RABGAP1L (Tier 1)
• Protein: RAB GTPase-activating protein 1-like, also known as TBC1D18. UniProt. GeneCards.
The allele that increases the risk of ME/CFS is associated with decreasing RABGAP1L gene expression.
• Molecular function: GTP-hydrolysis activating...
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