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Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing Highlights • Peripheral viral pattern sensing primes antiviral defenses in the CNS • Serum IFN-α is necessary and sufficient for the establishment of this antiviral...

Regulation of human interferon signaling by transposon exonization Giulia Irene Maria Pasquesi; Holly Allen; Atma Ivancevic; Arturo Barbachano-Guerrero; Olivia Joyner; Kejun Guo; David M. Simpson; Keala Gapin; Isabella Horton; Lily L. Nguyen; Qing Yang; Cody J. Warren; Liliana D. Florea...

Age-related transcript changes in type I interferon signaling in children and adolescents with long COVID Matteo Fracella; Enrica Mancino; Raffaella Nenna; Chiara Virgillito; Federica Frasca; Alessandra D'Auria; Leonardo Sorrentino; Laura Petrarca; Domenico La Regina; Luigi Matera; Greta Di...

Sex-dependent differences in type I IFN-induced natural killer cell activation Pujantell, Maria; Skenteris, Nikolaos-Taxiarchis; Claussen, Janna Marieke; Grünhagel, Benjamin; Thiele, Rebecca-Jo; Altfeld, Marcus Natural killer (NK) cells are important antiviral effector cells and also involved...

Mitochondrial DNA damage triggers spread of Parkinson’s disease-like pathology Tresse, Emilie; Marturia-Navarro, Joana; Sew, Wei Qi Guinevere; Cisquella-Serra, Marina; Jaberi, Elham; Riera-Ponsati, Lluis; Fauerby, Natasha; Hu, Erling; Kretz, Oliver; Aznar, Susana; Issazadeh-Navikas, Shohreh In...