Male and female mice achieve equivalent protection against heterologous SARS-CoV-2 infection through divergent immune mechanisms
Abstract
Biological sex is a major determinant of antiviral immunity, yet how it shapes lung-resident antiviral immunity remains poorly understood.
We report that...
Localized SARS-CoV-2 Infection Triggers a Tissue-Wide Antiviral Response and Functional Impairment of Olfactory Sensory Neurons
Abstract
Olfactory dysfunction is a hallmark of COVID-19, yet the mechanisms by which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes...
Acute viral infection accelerates neurodegeneration in a mouse model of ALS
Abstract
While several viral infections have been associated with amyotrophic lateral sclerosis (ALS), the mechanism(s) through which they promote disease remains elusive.
Here we investigate the impact of common...
STING recognition of viral dsDNA by nociceptors mediates pain in mice
https://www.sciencedirect.com/science/article/pii/S0889159124004823
Highlights
Nociceptors can directly sense viral nucleic acids, such as dsDNA derived from herpes and vaccinia viruses.
Cytosolic dsDNA causes nocifensive...
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.