interferon

Immune disturbances in individuals with post-COVID syndrome are not characterized by enhanced SARS-CoV-2-specific immunity Ober, Veronica; Völk, Felix; Sbierski-Kind, Julia; Gruener, Eva; Stirner, Renate; Reiling, Gabriele; Feldmann, Svenja; Ibarra, Gerardo; Seybold, Ulrich; Stubbe, Hans...

Hyper-reactivity of CD8+ T cells and high expression of IL-3 correlates with occurrence and severity of Long-COVID Renner; Stauffenberg; Paulus; Neumayer; Winter-Köhler; Buchtler; Schmalenberger; Blaas; Mohr; Pfeifer; Malfertheiner; Loew; Sester; Bals; Peterhoff; Schmidt; Mack Following...

[Clinical characteristics and cytokine gene expression in patients with post-COVID-19 syndrome] María Magdalena Valencia-Gutiérrez , Modesto Gómez-López, Nadia Mabel Pérez-Vielma, Paulina Lázaro-Aguilar, Víctor Ricardo Aguilera-Sosa Background Post-COVID-19 syndrome occurs 3 months after...

Abstract The immunoregulatory metabolite itaconate accumulates in innate immune cells upon Toll-like receptor stimulation. In response to macrophage activation by lipopolysaccharide, itaconate inhibits inflammasome activation and boosts type I interferon signalling; however, the molecular...

A new study reveals a surprising mechanism by which itaconate inhibits the active site of a peroxiredoxin enzyme to amplify redox signalling and the type I interferon response in macrophages. Paywalled

Effects of a mild inflammatory challenge on cytokines and sickness behavior: A randomized controlled trial using the influenza vaccine Jolink; Feldman; Antenucci; Cardenas; West; Nakamura; Muscatell The influenza vaccine has reliably been associated with mild, within-person increases in...

Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19 Ronaldo Lira-Junior; Anoop Ambikan; Axel Cederholm; Ssefanit Rezene; Flora Mikaeloff; Sara Svensson Akusjarvi; Ahmet Yalcinkaya; Xi Chen; Maike Sperk...

Unveiling the Immune Landscape of COVID-19 and prolonged Long-COVID through Single-Cell RNA Sequencing Marta Līva Spriņģe; Kristīne Vaivode; Rihards Saksis; Nineļa Miriama Vainšeļbauma; Laura Ansone; Monta Brīvība; Helvijs Niedra; Vita Rovite Long-COVID affects at least 10% of COVID-19...

The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination Maatz, Henrike; Lindberg, Eric L.; Adami, Eleonora; López-Anguita, Natalia; Perdomo-Sabogal, Alvaro; Cocera Ortega, Lucía; Patone, Giannino; Reichart...

Abstract Post-acute sequelae of COVID-19 (PASC) is a complex and multifaceted clinical challenge requiring to emphasize its underlying pathophysiological mechanisms. This study assessed hundreds of virological, serological, immunological, and tissue damage biomarkers in two patient cohorts who...

Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Abu Mohammad Syed; Alexander K. Karius; Jin Ma; Ping-yuan Wang; Paul M. Hwang ME/CFS is a debilitating multisystem disorder of unclear etiology that affects many individuals worldwide. One of its hallmark symptoms...

Polymerized Type I Collagen Downregulates STAT-1 Phosphorylation Through Engagement with LAIR-1 in Circulating Monocytes, Avoiding Long COVID Olivares-Martínez, Elizabeth; Hernández-Ramírez, Diego Francisco; Núñez-Álvarez, Carlos Alberto; Meza-Sánchez, David Eduardo; Chapa, Mónica...

Correlation of Interferons and Autoimmune Aspects in Long COVID-19 Patients Fumiyuki Hattori, Junji Nishiyama, Hideaki Hasuo [Line break added] Abstract Long COVID, or post-acute sequelae of COVID-19 (PASC), represents a major global health challenge, with its underlying mechanisms remaining...

Regulation of human interferon signaling by transposon exonization Giulia Irene Maria Pasquesi; Holly Allen; Atma Ivancevic; Arturo Barbachano-Guerrero; Olivia Joyner; Kejun Guo; David M. Simpson; Keala Gapin; Isabella Horton; Lily L. Nguyen; Qing Yang; Cody J. Warren; Liliana D. Florea...

An ultra-early, transient interferon-associated innate immune response associates with protection from SARS-CoV-2 infection despite exposure Joe Fenn et 77 al BACKGROUND A proportion of individuals exposed to respiratory viruses avoid contracting detectable infection. We tested the hypothesis...

Nuclear factor kappa-B cell NF-κB, interferon regulatory Factor, and glucocorticoid receptor pathway activation in major depressive Disorder: The role of cytomegalovirus infection Savitz; McKinney; Meier; Zheng; Ford; Yolken; Teague; Cole Altered activity of major immunoregulatory pathways has...

Immune exhaustion in ME/CFS and long COVID Natalie Eaton-Fitch; Penny Rudd; Teagan Er; Livia Hool; Lara Herrero; Sonya Marshall-Gradisnik Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are debilitating multisystemic conditions sharing similarities in immune...

STING recognition of viral dsDNA by nociceptors mediates pain in mice https://www.sciencedirect.com/science/article/pii/S0889159124004823 Highlights Nociceptors can directly sense viral nucleic acids, such as dsDNA derived from herpes and vaccinia viruses. Cytosolic dsDNA causes nocifensive...

Macro- and Microstructural White Matter Differences in Neurologic Postacute Sequelae of SARS-CoV-2 Infection Erin E. O’Connor; Rosangela Salerno-Goncalves; Nikita Rednam; Rory O’Brien; Peter Rock; Andrea R. Levine; Thomas A. Zeffiro BACKGROUND AND PURPOSE Neuropsychiatric complications of...

Type I interferons and endoplasmic reticulum stress in health and disease Sprooten; Garg Type I interferons (IFNs) comprise of pro-inflammatory cytokines created, as well as sensed, by all nucleated cells with the main objective of blocking pathogens-driven infections. Owing to this broad range...