kynurenine

Untargeted Metabolomics and Quantitative Analysis of Tryptophan Metabolites in Myalgic Encephalomyelitis Patients and Healthy Volunteers: A Comparative Study Using High-Resolution Mass Spectrometry Sandy Abujrais; Theodosia Vallianatou; Jonas Bergquist Myalgic encephalomyelitis/chronic fatigue...

The Complex World of Kynurenic Acid: Reflections on Biological Issues and Therapeutic Strategy Stone, Trevor W.; Darlington, L. Gail; Badawy, Abdulla A.-B.; Williams, Richard O. It has been unequivocally established that kynurenic acid has a number of actions in a variety of cells and tissues...

Exploring Metabolic Anomalies in COVID-19 and Post-COVID-19: A Machine Learning Approach with Explainable Artificial Intelligence Juan José Oropeza-Valdez; Cristian Padron-Manrique; Aaron Vazquez-Jimenez; Xavier Soberon-Mainero; Osbaldo Resendis-Antonio The COVID-19 pandemic, caused by...

Abstract Dysregulation of the kynurenine pathway (KP) is believed to play a significant role in neurodegenerative and cognitive disorders. While some evidence links the KP to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), further studies are needed to clarify the overall picture of...

Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants Jeremy P. Gygi; Cole Maguire; Ravi K. Patel; Pramod Shinde; Anna Konstorum; Casey P. Shannon; Leqi Xu; Annmarie Hoch; Naresh Jayavelu; IMPACC...

Integrative Plasma Metabolic and Lipidomic Modelling of SARS-CoV-2 Infection in Relation to Clinical Severity and Early Mortality Prediction Lodge, Samantha; Lawler, Nathan G.; Gray, Nicola; Masuda, Reika; Nitschke, Philipp; Whiley, Luke; Bong, Sze-How; Yeap, Bu B.; Dwivedi, Girish; Spraul...

The kynurenine pathway relates to post-acute COVID-19 objective cognitive impairment and PASC Abstract Objective To determine the prevalence and natural history of post-acute COVID-19 objective cognitive impairment and function, and their relationship to demographic, clinical factors...

Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection Background Post-acute sequela of SARS-CoV-2 infection (PASC) encompass fatigue, post-exertional malaise and cognitive problems. The abundant expression of the...

Immunometabolic rewiring in long COVID patients with chronic headache Suan-Sin Foo, Weiqiang Chen, Kyle L Jung, Tamiris Azamor, Un Yung Choi, Pengfei Zhang, Suzy AA Comhair, Serpil C Erzurum, Lara Jehi, Jae U Jung Almost 20% of patients with COVID-19 experience long-term effects, known as...

Abstract The biology driving individual patient responses to severe acute respiratory syndrome coronavirus 2 infection remains ill understood. Here, we developed a patient-centric framework leveraging detailed longitudinal phenotyping data and covering a year after disease onset, from 215...

Abstract The causes of depression are diverse and are still not fully understood. Recently, an increasing role is attributed to nutritional and inflammatory factors. The aim of this study was to evaluate selected metabolites of the tryptophan kynurenine pathway in depressive patients with small...

I present here a comparison between the levels of tryptophan (Trp), kynurenine (Kyn), serotonin (Ser), Kyn/Trp, and Ser/Trp in cerebrospinal fluid of 44 ME/CFS patients vs 21 sedentary controls. Raw data were retrieved from (Baraniuk JN et al. 2021). Stratification by sex has been included in...

Aussie breakthrough on the long Covid condition that leaves sufferers with symptoms similar to 'traumatic brain injury (Daily Mail - no really) (Kynurenine) ETA: Dr Bruce Brew recently co-authored Recent advances in clinical trials targeting the kynurenine pathway (Pires et al, 2021)

Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, complex, and highly debilitating long-term illness. People with ME/CFS are typically unable to carry out their routine activities. Key hallmarks of the disease are neurological and gastrointestinal impairments...

Tryptophan and the innate intestinal immunity: Crosstalk between metabolites, host innate immune cells, and microbiota Yunke Li, Ning Liu, Yao Ge, Ying Yang, Fazheng Ren, Zhenlong Wu Abstract The intestinal mucosal barrier is critical for the absorption of nutrients and the health of both...

Abstract Background The tryptophan–kynurenine–nicotinamide adenine dinucleotide (oxidized; NAD+) pathway is closely associated with regulation of immune cells toward less inflammatory phenotypes and may exert neuroprotective effects. Investigating its regulation in central nervous system (CNS)...

Zika virus (ZIKV) is an arbovirus belonging to Flaviviridae family that emerged as a global health threat due to its association with microcephaly and other severe neurological complications, including Guillain-Barré Syndrome (GBS) and Congenital Zika Syndrome (CZS). ZIKV disease has been linked...

Abstract Chronic stress is associated with an increased conversion of tryptophan (TRP) into kynurenine (KYN). However, only a few studies investigated KYN pathway metabolite concentrations following acute stress in healthy subjects. We hypothesized that TRP/KYN metabolism changes following...

Abstract The kynurenine pathway (KP) is the main path for tryptophan metabolism, and it represents a multitude of potential sites for drug discovery in neuroscience, including pain, stroke, and epilepsy. L‐kynurenine (LKYN), the first active metabolite in the pathway, emerges to be a prodrug...

Full title: Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition? Open access, https://www.sciencedirect.com/science/article/pii/S1359644621000751