kynurenine

  1. Andy

    The Role of Kynurenine Pathway and NAD + Metabolism in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2022, Dehhaghi et al

    Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, complex, and highly debilitating long-term illness. People with ME/CFS are typically unable to carry out their routine activities. Key hallmarks of the disease are neurological and gastrointestinal impairments...
    • Andy
    • Thread
    • benjamin heng guillemin kynurenine me/cfs nad+ tryptophan
    • Replies: 18
    • Forum: ME/CFS research
  2. SNT Gatchaman

    Tryptophan and the innate intestinal immunity: Crosstalk between metabolites, host innate immune cells, and microbiota: 2022, Li et al

    Tryptophan and the innate intestinal immunity: Crosstalk between metabolites, host innate immune cells, and microbiota Yunke Li, Ning Liu, Yao Ge, Ying Yang, Fazheng Ren, Zhenlong Wu Abstract The intestinal mucosal barrier is critical for the absorption of nutrients and the health of both...
  3. Mij

    Kynurenine Is a Cerebrospinal Fluid Biomarker for Bacterial and Viral Central Nervous System Infections, 2019, Sühs et al

    Abstract Background The tryptophan–kynurenine–nicotinamide adenine dinucleotide (oxidized; NAD+) pathway is closely associated with regulation of immune cells toward less inflammatory phenotypes and may exert neuroprotective effects. Investigating its regulation in central nervous system (CNS)...
  4. Andy

    Inhibition of Tryptophan Catabolism Is Associated With Neuroprotection During Zika Virus Infection, 2021, Martins Marim et al

    Zika virus (ZIKV) is an arbovirus belonging to Flaviviridae family that emerged as a global health threat due to its association with microcephaly and other severe neurological complications, including Guillain-Barré Syndrome (GBS) and Congenital Zika Syndrome (CZS). ZIKV disease has been linked...
  5. Andy

    Changes in Kynurenine Pathway Metabolites After Acute Psychosocial Stress in Healthy Males: A Single-Arm Pilot Study, 2021, La Torre et al

    Abstract Chronic stress is associated with an increased conversion of tryptophan (TRP) into kynurenine (KYN). However, only a few studies investigated KYN pathway metabolite concentrations following acute stress in healthy subjects. We hypothesized that TRP/KYN metabolism changes following...
  6. Possibly James May

    Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers, 2021, Al-Karagholi et al

    Abstract The kynurenine pathway (KP) is the main path for tryptophan metabolism, and it represents a multitude of potential sites for drug discovery in neuroscience, including pain, stroke, and epilepsy. L‐kynurenine (LKYN), the first active metabolite in the pathway, emerges to be a prodrug...
  7. Andy

    Inflammation control & improvement of cognitive function in COVID-19: is there a role for kynurenine 3-monooxygenase inhibition?, Collier et al, 2021

    Full title: Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition? Open access, https://www.sciencedirect.com/science/article/pii/S1359644621000751
  8. Andy

    Searching for Peripheral Biomarkers in Neurodegenerative Diseases: The Tryptophan-Kynurenine Metabolic Pathway, 2020, Torok et al

    Open access, https://www.mdpi.com/1422-0067/21/24/9338/htm
  9. Sid

    Molecular Psychiatry (2020): The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies

    Abstract The importance of tryptophan as a precursor for neuroactive compounds has long been acknowledged. The metabolism of tryptophan along the kynurenine pathway and its involvement in mental disorders is an emerging area in psychiatry. We performed a meta-analysis to examine the...
  10. J

    Evidence of Structural Protein Damage and Membrane Lipid Remodeling in Red Blood Cells from COVID-19 Patients, 2020, Thomas et al

    Both red blood cells damage and kynurine identified in LongCovid research https://news.cuanschutz.edu/news-stories/attack-on-red-blood-cells-a-prime-suspect-in-covids-debilitating-effects?fbclid=IwAR2BjzW8TolU6d1b-VxUN-n6F55E6dMVcMwGkMR-huuW-wbi8mEvqTNJt-s
  11. J

    Kynurenine pathway is altered in patients with SLE and associated with severe fatigue, 2018, Akesson et al.

    https://lupus.bmj.com/content/5/1/e000254
  12. J

    Potential Role of Neuroactive Tryptophan Metabolites in Central Fatigue: Establishment of the Fatigue Circuit, 2020, Yamashita

    https://journals.sagepub.com/doi/full/10.1177/1178646920936279
  13. Andy

    Hepatocyte-intrinsic type I interferon signaling reprograms metabolism [..] compensatory mechanism of the tryptophan-kynurenine pathway, 2020, Lercher

    Full title: Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis Open access, https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008973
  14. Sly Saint

    Kynurenine Trial in ME/CFS - Bergquist

    STUDY AIM The purpose of the study is to evaluate whether kynurenine is directly connected to ME/CFS patient symptom severity. LEAD INVESTIGATORS Jonas Bergquist, MD, PhD, Prof, Director ScD Kumari Ubhayasekhera, PhD Sandy Abujrais. PhD Student further details here...
  15. Andy

    COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status, 2020, Thomas et al

    Open access, https://insight.jci.org/articles/view/140327/pdf
  16. Andy

    Increased Expression of (IDO) in Vogt-Koyanagi-Harada (VKH) Disease May Lead to a Shift of T Cell Responses Toward a Treg Population, 2020,Zhang et al

    Full title: Increased Expression of Indoleamine 2,3-Dioxygenase (IDO) in Vogt-Koyanagi-Harada (VKH) Disease May Lead to a Shift of T Cell Responses Toward a Treg Population Paywall, https://link.springer.com/article/10.1007/s10753-020-01252-7 Sci hub, https://sci-hub.tw/10.1007/s10753-020-01252-7
  17. cassava7

    OMF to launch clinical trials on Mestinon & Kynurenine, post-COVID19 study

    From their May Momentum 2020 newsletter & https://www.omf.ngo/maymomentum/ Post-COVID19 study: https://www.omf.ngo/2020/04/26/tracking-covid-19-patients/ Mestinon trial: https://www.omf.ngo/2020/04/26/the-mestinon-clinical-trial-for-me-cfs/ &...
    • cassava7
    • Thread
    • clinical trial covid-19 kynurenine me/cfs mestinon omf post covid-19 syndrome rct
    • Replies: 36
    • Forum: ME/CFS research news
  18. Andy

    The Kynurenine connection: how exercise shifts muscle tryptophan metabolism & affects energy homeostasis, the immune system & the brain, 2020, Martin

    Paywall, https://journals.physiology.org/doi/abs/10.1152/ajpcell.00580.2019 Sci-hub not available at time of posting.
  19. Andy

    Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder, 2020, Sakurai et al

    Open access, https://www.nature.com/articles/s41598-020-58806-w
  20. John Mac

    The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS 2019 Kashi, Davis, Phair.

    https://www.mdpi.com/2075-4418/9/3/82
    • John Mac
    • Thread
    • 2019 guillemin kashi kynurenine me/cfs metabolic trap paper pathogenesis phair ron davis tryptophan
    • Replies: 49
    • Forum: ME/CFS research
Back
Top Bottom