kynurenine

  1. Andy

    Searching for Peripheral Biomarkers in Neurodegenerative Diseases: The Tryptophan-Kynurenine Metabolic Pathway, 2020, Torok et al

    Open access, https://www.mdpi.com/1422-0067/21/24/9338/htm
  2. Sid

    Molecular Psychiatry (2020): The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies

    Abstract The importance of tryptophan as a precursor for neuroactive compounds has long been acknowledged. The metabolism of tryptophan along the kynurenine pathway and its involvement in mental disorders is an emerging area in psychiatry. We performed a meta-analysis to examine the...
  3. J

    Evidence of Structural Protein Damage and Membrane Lipid Remodeling in Red Blood Cells from COVID-19 Patients, 2020, Thomas et al

    Both red blood cells damage and kynurine identified in LongCovid research https://news.cuanschutz.edu/news-stories/attack-on-red-blood-cells-a-prime-suspect-in-covids-debilitating-effects?fbclid=IwAR2BjzW8TolU6d1b-VxUN-n6F55E6dMVcMwGkMR-huuW-wbi8mEvqTNJt-s
  4. J

    Kynurenine pathway is altered in patients with SLE and associated with severe fatigue, 2018, Akesson et al.

    https://lupus.bmj.com/content/5/1/e000254
  5. J

    Potential Role of Neuroactive Tryptophan Metabolites in Central Fatigue: Establishment of the Fatigue Circuit, 2020, Yamashita

    https://journals.sagepub.com/doi/full/10.1177/1178646920936279
  6. Andy

    Hepatocyte-intrinsic type I interferon signaling reprograms metabolism [..] compensatory mechanism of the tryptophan-kynurenine pathway, 2020, Lercher

    Full title: Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis Open access, https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008973
  7. Sly Saint

    Kynurenine Trial in ME/CFS - Bergquist

    STUDY AIM The purpose of the study is to evaluate whether kynurenine is directly connected to ME/CFS patient symptom severity. LEAD INVESTIGATORS Jonas Bergquist, MD, PhD, Prof, Director ScD Kumari Ubhayasekhera, PhD Sandy Abujrais. PhD Student further details here...
  8. Andy

    COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status, 2020, Thomas et al

    Open access, https://insight.jci.org/articles/view/140327/pdf
  9. Andy

    Increased Expression of (IDO) in Vogt-Koyanagi-Harada (VKH) Disease May Lead to a Shift of T Cell Responses Toward a Treg Population, 2020,Zhang et al

    Full title: Increased Expression of Indoleamine 2,3-Dioxygenase (IDO) in Vogt-Koyanagi-Harada (VKH) Disease May Lead to a Shift of T Cell Responses Toward a Treg Population Paywall, https://link.springer.com/article/10.1007/s10753-020-01252-7 Sci hub, https://sci-hub.tw/10.1007/s10753-020-01252-7
  10. cassava7

    OMF to launch clinical trials on Mestinon & Kynurenine, post-COVID19 study

    From their May Momentum 2020 newsletter & https://www.omf.ngo/maymomentum/ Post-COVID19 study: https://www.omf.ngo/2020/04/26/tracking-covid-19-patients/ Mestinon trial: https://www.omf.ngo/2020/04/26/the-mestinon-clinical-trial-for-me-cfs/ &...
    • cassava7
    • Thread
    • clinical trial covid-19 kynurenine me/cfs mestinon omf post covid-19 syndrome rct
    • Replies: 36
    • Forum: ME/CFS research news
  11. Andy

    The Kynurenine connection: how exercise shifts muscle tryptophan metabolism & affects energy homeostasis, the immune system & the brain, 2020, Martin

    Paywall, https://journals.physiology.org/doi/abs/10.1152/ajpcell.00580.2019 Sci-hub not available at time of posting.
  12. Andy

    Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder, 2020, Sakurai et al

    Open access, https://www.nature.com/articles/s41598-020-58806-w
  13. John Mac

    The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS 2019 Kashi, Davis, Phair.

    https://www.mdpi.com/2075-4418/9/3/82
    • John Mac
    • Thread
    • 2019 guillemin kashi kynurenine me/cfs metabolic trap paper pathogenesis phair ron davis tryptophan
    • Replies: 49
    • Forum: ME/CFS research
  14. MeSci

    Persistent fatigue induced by interferon-alpha: A novel, inflammation-based, proxy model of Chronic Fatigue Syndrome, 2018, Pariante et al

    Not sure whether this is really relevant, but the reference to kynurenine looked interesting. NB participants include some dodgy people, e.g. Trudie Chalder. Source: University of Essex (or Sussex?) Date: November 29, 2018 URL: http://sro.sussex.ac.uk/80506/ Persistent fatigue induced by...
    • MeSci
    • Thread
    • bps chalder inflammation interferon interferon-alpha kynurenine me/cfs meruk pariante psychoneuroimmunology
    • Replies: 460
    • Forum: ME/CFS research
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