Hi, I am curious as to whether anyone has some developed hypotheses as to the mechanism of 'low-dose' Naltrexone? Much of the discourse about...
Abstract Introduction: Fibromyalgia (FM) is a chronic fluctuating, nociplastic pain condition. Naltrexone is a µ-opioid-receptor antagonist;...
Full title: Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the...
Discussion moved from the OMF news thread. Trial details - mestinon and/or LDN https://www.omf.ngo/lift-trial/
Highlights The off-label use of low-dose naltrexone (LDN) is a potential drug intervention for the management of post-COVID conditions. LDN...
This much cited (over 1600 citations) study from 1978 claims to have proven the placebo effect is real. https://pubmed.ncbi.nlm.nih.gov/80579/...
Abstract: Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS) is considered to be a multidimensional illness whose etiology is unknown....
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489802/ Open access Abstract Fibromyalgia (FM) is a complex, multi-symptom condition that...
https://link.springer.com/article/10.1007/s10067-014-2517-2 Open access Abstract Low-dose naltrexone (LDN) has been demonstrated to reduce...
The UK government working party on research strategy for ME has been discussing the value of setting up trials for drug repurposing. LDN is a...
The drug has been used with some success to treat a similar complex, post-infectious syndrome marked by cognitive deficits and overwhelming...
Highlights Low dose naltrexone (LDN) is safe to use in patients with long covid (LC). In patients with LC for a median 11 months, LDN reduced...
Clinical trial registration. There is a growing number of individuals who do not recover to previous levels of health and function following an...
Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious disorder of unknown aetiology. While the...
Full title: Study protocol for a randomised, double-blinded, placebo-controlled phase III trial examining the add-on efficacy, cost-utility and...
Full title: Potential therapeutic benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor...
Abstract Naltrexone is used as an off-label treatment in low doses for several chronic immune-modulated disorders in many countries. Although only...
Low-dose naltrexone in the treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)...
"Naltrexone restores impaired transient receptor potential melastatin 3 ion channel function in natural killer cells from myalgic...
The new @dave30th 's article The PACE trial and other unacceptable studies from the CBT/GET ideological brigades have had an enormous impact...
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