macrophages

  1. leokitten

    Splicing QTL mapping in stimulated macrophages associates low-usage splice junctions with immune-mediated disease risk, Garwany et al 2025

    The majority of immune-mediated disease (IMD) risk loci are located in non-coding regions of the genome, making it difficult to decipher their functional effects in relevant physiological contexts. To assess the extent to which alternative splicing contributes to IMD risk, we mapped genetic...
  2. leokitten

    Gene expression QTL mapping in stimulated iPSC-derived macrophages provides insights into common complex diseases, Panousis et al 2025

    Many disease-associated variants are thought to be regulatory but are not present in existing catalogues of expression quantitative trait loci (eQTL). We hypothesise that these variants may regulate expression in specific biological contexts, such as stimulated immune cells. Here, we used human...
  3. forestglip

    Preprint Identification and Validation of Novel Combinatorial Genetic Risk Factors for Endometriosis across Multiple UK and US Patient Cohorts, 2025, Sardell+

    Identification and Validation of Novel Combinatorial Genetic Risk Factors for Endometriosis across Multiple UK and US Patient Cohorts JM Sardell, S Das, GL Møller, M Sanna, K Chocian, K Taylor, AR Malinowski, C Stubberfield, A Rochlin, S Gardner Background Endometriosis affects about 10% of...
  4. forestglip

    Thesis YKL-40 as a biomarker for long-term changes in innate immunity after COVID-19 onset, 2025, Sheng

    YKL-40 as a biomarker for long-term changes in innate immunity after COVID-19 onset Youjing Sheng Supervisor: Kzhyshkowska, Prof. Dr. rer. nat. Julia [Line breaks added] Abstract In the complex landscape of COVID-19 research, a particular area of interest is the study of individuals who have...
  5. forestglip

    Hypothesis Perspective: host factors variants and the underlying causes of long COVID, 2025, Pasharawipas

    Perspective: host factors variants and the underlying causes of long COVID Tirasak Pasharawipas Long COVID, also known as post-COVID syndrome (PCS), is characterized by persistent and unexplained symptoms that can occur not only in individuals who experienced severe symptoms during the acute...
  6. Jonathan Edwards

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    Link to the thread on the preprint - 27 May 2025: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff ****** I am hoping that the paper I have been writing with Jo Cambridge and Jackie Cliff will appear on Qeios tomorrow. If...
  7. jnmaciuch

    Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-γ stimulation, 2020, Seim et al.

    Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-γ stimulation Gretchen L Seim, Emily C Britt, Steven V John, Franklin J Yeo, Aaron R Johnson, Richard S Eisenstein, David J Pagliarini, Jing Fan Abstract In response to signals associated with...
  8. jnmaciuch

    Malate initiates a proton-sensing pathway essential for pH regulation of inflammation, 2024, Chen et al.

    Malate initiates a proton-sensing pathway essential for pH regulation of inflammation Yu-jia-nan Chen, Rong-chen Shi, Yuan-cai Xiang, Li Fan, Hong Tang, Gang He, Mei Zhou, Xin-zhe Feng, Jin-dong Tan, Pan Huang, Xiao Ye, Kun Zhao, Wen-yu Fu, Liu-li Li, Xu-ting Bian, Huan Chen, Feng Wang, Teng...
  9. jnmaciuch

    Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages, 2018, Wang et al.

    Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity Feilong Wang ∙ Song Zhang ∙ Ryounghoon Jeon ∙ Ivan Vuckovic ∙ Xintong Jiang∙ Amir Lerman∙ Clifford D. Folmes ∙ Petras D. Dzeja ∙ Joerg Herrmann Highlights...
  10. Mij

    Itaconate modulates immune responses via inhibition of peroxiredoxin 5, 2025, Tomas Paulenda et al

    Abstract The immunoregulatory metabolite itaconate accumulates in innate immune cells upon Toll-like receptor stimulation. In response to macrophage activation by lipopolysaccharide, itaconate inhibits inflammasome activation and boosts type I interferon signalling; however, the molecular...
    • Mij
    • Thread
    • interferon itaconate macrophages paulenda peroxiredoxin prdx2 prdx6 ros
    • Replies: 233
    • Forum: Other health news and research
  11. SNT Gatchaman

    Neutrophil extracellular traps and macrophage activation [contribute] to thrombosis and post-covid syndrome […], 2025, Serrano-Gonzalo+

    Neutrophil extracellular traps and macrophage activation contibute to thrombosis and post-covid syndrome in SARS-CoV-2 infection Serrano-Gonzalo, Irene; Menéndez-Jandula, Bárbara; Franco-García, Esther; Arévalo-Vargas, Isidro; Lahoz-Gil, Calos; Latre, Paz; Roca-Esteve, Sonia; Köhler, Ralf; López...
  12. forestglip

    340 – Monocyte Dysregulation in PASC With Ongoing Pulmonary Symptoms, 2025, Awamura et al

    340 – Monocyte Dysregulation in PASC With Ongoing Pulmonary Symptoms Thomas K. Awamura, Stefanos Giannakopoulos, Dominic C. Chow, Cecilia M. Shikuma, Gehan Devendra, Vedbar Khadka, Juwon Park Background As the number of COVID-19 survivors amongst the global population continues to rise, the...
    • forestglip
    • Thread
    • chronic inflammatory disorder il-10 il-6 il-8 inflammation interstitial pneumonia long covid macrophages monocytes neutrophils nitric oxide reactive oxygen species vasculitis
    • Replies: 1
    • Forum: Long Covid research
  13. forestglip

    Thesis Clinical, histopathological, and radiological characterization of post-acute sequelae of COVID-19, 2025, Czech

    Clinical, histopathological, and radiological characterization of post-acute sequelae of COVID-19 Anna Czech Abstract Numerous patients exhibit enduring symptoms following a Coronavirus Disease 2019 (COVID-19) infection, termed Post-Acute Sequelae of COVID-19 (PASC). The typical manifestations...
    • forestglip
    • Thread
    • cd4+ fev1 fibrinous alveolitis forced vital capacity il-1b lav long covid macrophages organizing pneumonia oxygen pulse t cells viral persistence
    • Replies: 0
    • Forum: Long Covid research
  14. SNT Gatchaman

    Polymerized Type I Collagen Downregulates STAT-1 Phosphorylation Through Engagement with LAIR-1 in Monocytes, Avoiding [LC], 2025, Olivares-Martínez+

    Polymerized Type I Collagen Downregulates STAT-1 Phosphorylation Through Engagement with LAIR-1 in Circulating Monocytes, Avoiding Long COVID Olivares-Martínez, Elizabeth; Hernández-Ramírez, Diego Francisco; Núñez-Álvarez, Carlos Alberto; Meza-Sánchez, David Eduardo; Chapa, Mónica...
  15. SNT Gatchaman

    Exercise intensity and training alter the innate immune cell type and chromosomal origins of circulating cell-free DNA in humans, 2025, Rodrigues+

    Exercise intensity and training alter the innate immune cell type and chromosomal origins of circulating cell-free DNA in humans Rodrigues, Kameron B.; Weng, Ziming; Graham, Zachary A.; Lavin, Kaleen; McAdam, Jeremy; Tuggle, S. Craig; Peoples, Brandon; Seay, Regina; Yang, Sufen; Bamman, Marcas...
  16. Mij

    Persistent Fatigue, Weakness, and Aberrant Muscle Mitochondria in Survivors of Critical COVID-19, 2024, Kirby P Mayer et al

    KEY POINTS Question: Determine the short- and long-term physical impairments and skeletal muscle cellular changes in survivors of critical COVID. Findings: Survivors of critical COVID have high prevalence of weakness, fatigue, and reduced functional exercise capacity with muscle tissue...
    • Mij
    • Thread
    • cd206 cytochrome c oxidase intensive care macrophages mitochondria muscle muscle biopsy muscle fibre
    • Replies: 2
    • Forum: Long Covid research
  17. SNT Gatchaman

    An aberrant immune–epithelial progenitor niche drives viral lung sequelae, 2024, Narasimhan et al.

    An aberrant immune–epithelial progenitor niche drives viral lung sequelae Narasimhan, Harish; Cheon, In Su; Qian, Wei; Hu, Sheng’en Shawn; Parimon, Tanyalak; Li, Chaofan; Goplen, Nick; Wu, Yue; Wei, Xiaoqin; Son, Young Min; Fink, Elizabeth; de Almeida Santos, Gislane; Tang, Jinyi; Yao, Changfu...
  18. SNT Gatchaman

    The choroid plexus synergizes with immune cells during neuroinflammation, 2024, Xu et al.

    The choroid plexus synergizes with immune cells during neuroinflammation Huixin Xu; Peter Lotfy; Sivan Gelb; Aja Pragana; Christine Hehnly; Lillian I.J. Byer; Frederick B. Shipley; Miriam E. Zawadzki; Jin Cui; Liwen Deng; Milo Taylor; Mya Webb; Hart G.W. Lidov; Mark L. Andermann; Isaac M. Chiu...
    • SNT Gatchaman
    • Thread
    • blood brain barrier blood csf barrier cerebrospinal fluid choroid plexus immune system innate immune response macrophages monocytes neuroinflammation neutrophils
    • Replies: 1
    • Forum: Other health news and research
  19. SNT Gatchaman

    Preprint Innate Immune Activation and Mitochondrial ROS Invoke Persistent Cardiac Conduction System Dysfunction after COVID-19, 2024, Ashok et al.

    Innate Immune Activation and Mitochondrial ROS Invoke Persistent Cardiac Conduction System Dysfunction after COVID-19 Deepthi Ashok; Ting Liu; Joseph Criscione; Meghana Prakash; Byunggik Kim; Julian Chow; Morgan Craney; Kyriakos Papanicolaou; Agnieszka Sidor; D. Brian Foster; Andrew Pekosz...
    • SNT Gatchaman
    • Thread
    • arrhythmia cardiac cardiac function cytokines innate immune response interferon interferon-stimulated genes jak inhibitors jak-stat macrophages mitochondria reactive oxygen species
    • Replies: 0
    • Forum: Long Covid research
  20. SNT Gatchaman

    Macrophage SREBP1 regulates skeletal muscle regeneration, 2024, Oishi et al.

    Macrophage SREBP1 regulates skeletal muscle regeneration Oishi, Yumiko; Koike, Hiroyuki; Kumagami, Naoki; Nakagawa, Yoshimi; Araki, Masaya; Taketomi, Yoshitaka; Miki, Yoshimi; Matsuda, Shigeru; Matsuzaka, Takashi; Ozawa, Hitoshi; Shimano, Hitoshi; Murakami, Makoto; Manabe, Ichiro Macrophages...
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