Astrocytic mitochondrial transfer to brain endothelial cells and pericytes in vivo increases with aging
Gopal V Velmurugan; Hemendra J Vekaria; Samir P Patel; Patrick G Sullivan; W Brad Hubbard
Intercellular mitochondrial transfer (IMT) is an intriguing biological phenomenon where mitochondria...
Significance
We used a back-translational approach in mice to demonstrate the pronociceptive role of neutrophils in fibromyalgia. Adoptive transfer of neutrophils from mice with chronic widespread pain or from patients with fibromyalgia can confer mechanical pain to recipient naïve mice...
Highlights
• Mitochondrial stress stimulates adipocyte sEV release
• Adipocyte stress-induced sEVs are enriched with oxidatively damaged mitochondria
• Mitochondria in sEVs from stressed adipocytes induce a burst of ROS in cardiac tissue
• The adipocyte-derived pro-oxidant signal protects...
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