natural killer cells

Low-Dose Naltrexone restored TRPM3 ion channel function in Natural Killer cells from long COVID patients Etianne Martini Sasso, Natalie Eaton-Fitch, Peter Kenneth Smith, Muraki Katsuhiko, Sonya Marshall-Gradisnik [Line breaks] Abstract Long COVID is a multisystemic condition that includes...

Reduced Natural Killer (NK) cell cytotoxicity is the most consistent immune finding in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS). Meta-analysis of the published literature determined the effect size of the decrement in ME/CFS. Databases were screened for papers comparing NK...

Link to paper Abstract NK cell cytotoxicity is a widely used measure to determine the effect of outside intervention on NK cell function. However, the accuracy and reproducibility of this assay can be considered unstable, either because of user's errors or because of the sensitivity of NK...

Full title: Investigation into the restoration of TRPM3 ion channel activity in post COVID-19 condition: a potential pharmacotherapeutic target Recently, we reported that post COVID-19 condition patients also have Transient Receptor Potential Melastatin 3 (TRPM3) ion channel dysfunction, a...

Recognition of herpesviruses by the innate immune system Paludan, Søren R.; Bowie, Andrew G.; Horan, Kristy A.; Fitzgerald, Katherine A. Advances in innate immunity over the past decade have revealed distinct classes of pattern recognition receptors (PRRs) that detect pathogens at the cell...

Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations Jennifer R. Habel; Brendon Y. Chua; Lukasz Kedzierski; Kevin J. Selva; Timon Damelang; Ebene R. Haycroft; Thi H.O. Nguyen; Hui-Fern Koay; Suellen Nicholson; Hayley A. McQuilten; Xiaoxiao Jia...

https://www.mdpi.com/1422-0067/24/3/2010 Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disabling multisystem illness in which individuals are plagued with fatigue, inflammatory symptoms, cognitive dysfunction, and the hallmark symptom, post-exertional malaise. While...

SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D Madeline J. Lee, Michelle W. Leong, Arjun Rustagi, Aimee Beck, Leiping Zeng, Susan Holmes,4 Lei S. Qi, Catherine A. Blish Natural killer (NK) cells are cytotoxic effector cells that target and...

Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious disorder of unknown aetiology. While the pathomechanism of ME/CFS remains elusive, reduced natural killer (NK) cell cytotoxic function is a consistent immunological feature. NK cell effector functions...

https://www.frontiersin.org/articles/10.3389/fimmu.2017.00723/full Correction article https://www.frontiersin.org/articles/10.3389/fimmu.2019.00350/full

Pilot assessment of low NK cell-mediated ADCC and FCGR3A genetics in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Based on inclusion of family members without ME/CFS as controls, low ADCC is unsuitable as a diagnostic biomarker Alexander P. Sung, Jennifer J-J Tang, Michael J...

Abstract Background Compromised natural killer (NK) cell cytotoxic function is a well-documented and consistent feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Other outcomes evaluated in NK cells of ME/CFS patients, however, remain equivocal. The aim of this study was to...

"Naltrexone restores impaired transient receptor potential melastatin 3 ion channel function in natural killer cells from myalgic encephalomyelitis/chronic fatigue syndrome patients" https://www.frontiersin.org/articles/10.3389/fimmu.2019.02545/abstract (No full text yet.)

Open access at https://molmed.biomedcentral.com/articles/10.1186/s10020-019-0083-4

https://www.frontiersin.org/articles/10.3389/fimmu.2019.00796/abstract Full, open access, text here, https://www.frontiersin.org/articles/10.3389/fimmu.2019.00796/full ETA: Link to full text.

An old study but, as shown in this thread, https://s4me.info/threads/top-10-sc...f-citations-tweet-by-dr-mark-gutheridge.7461/, one of the most cited ME/CFS papers in the past 10 years, so thought it might be useful to have here. Paywalled at...

This thread has been split from here. As issues were quite intertwined, a number of posts have been copied. In copied posts, text not related to this topic has been greyed. This makes sense to me, but I am a bit more optimistic. CCC is probably not ideal for clinical classification but I...

https://www.ncbi.nlm.nih.gov/pubmed/30134818 https://molmed.biomedcentral.com/articles/10.1186/s10020-018-0046-1

https://www.ncbi.nlm.nih.gov/pubmed/29981562 The DOI (digital object identifier, aka ID number) for this doesn't seem to work, so I'm not sure anything beyond the abstract has been published yet.

http://jcb.rupress.org/content/early/2018/06/29/jcb.201712085