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Start on page 174 BC MEDICAL JOURNAL VOL. 67 NO. 5 | JUNE 2025 https://bcmj.org/sites/default/files/BCMJ_Vol67_No5_complete.pdf Health outcomes of patients in the Complex Chronic Diseases Program New approaches and research are urgently needed to improve therapeutic interventions for...

Abstract Low-dose naltrexone (LDN) has demonstrated mixed efficacy in treating fibromyalgia. This systematic review and meta-analysis aimed to evaluate the efficacy of LDN for fibromyalgia. We systematically searched electronic databases and gray literature from inception to May 2024. Included...

Ten sessions of hyperbaric oxygen versus sham treatment in patients with long covid HOT-LoCO: a randomised, placebo-controlled, double-blind, phase II trial Anders Kjellberg; Adrian Hassler; Emil Boström; Sara El Gharbi; Sarah Al-Ezerjawi; Anna Schening; Katarina Fischer; Jan H Kowalski; Kenny A...

Nirmatrelvir–ritonavir versus placebo–ritonavir in individuals with long COVID in the USA PAX LC: a double-blind, randomised, placebo-controlled, phase 2, decentralised trial Mitsuaki Sawano; Bornali Bhattacharjee; César Caraballo; Rohan Khera; Shu-Xia Li; Jeph Herrin; Dany Christian; Andreas...

Addressing post-COVID-19 musculoskeletal symptoms through pulmonary rehabilitation with an evidence-based eHealth education tool: Preliminary results from a pilot randomized controlled clinical trial Sánchez-Romero, Eleuterio A.; García-Barredo-Restegui, Teresa; Martínez-Rolando, Lidia...

Preliminary evaluation of a mindfulness intervention program in women with long COVID dysautonomia symptoms Vandenbogaart; Figueroa; Winston; Cole; Bower; Hsu BACKGROUND The symptom burden for patients with Long COVID-associated dysautonomia is high, yet there are currently no effective...

Plasma exchange therapy for the post COVID-19 condition: a phase II, double-blind, placebo-controlled, randomized trial España-Cueto, Sergio; Loste, Cora; Lladós, Gemma; López, Cristina; Santos, José Ramón; Dulsat, Gemma; García, Anna; Carmezim, João; Carabia, Julia; Ancochea, Águeda...

Lithium Aspartate for Long COVID Fatigue and Cognitive Dysfunction: A Randomized Clinical Trial Thomas Guttuso; Jingtao Zhu; Gregory E. Wilding IMPORTANCE Neurologic post–COVID-19 condition (PCC), or long COVID, symptoms of fatigue and cognitive dysfunction continue to affect millions of people...

Follow-up of patients with post covid-19 condition after a multidisciplinary team assessment: a pilot study Alexander Wigge; Johanna Philipson; Solveig Hällgren; Helena Filipsson; Britt-Marie Stålnacke OBJECTIVES To follow up patients with post-COVID-19 condition (PCC) 6 months after a...

Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort 60 authors ; on behalf of the RECOVER-Adult Cohort BACKGROUND There are currently no validated clinical biomarkers of postacute sequelae of SARS-CoV-2...

One trial has resulted in three papers. As well as this main paper, there is: Which factors predict outcome from specialist physiotherapy for functional motor disorder?... 2025, Nielsen, Stone, Carson, Edwards et al Cost Utility of Specialist Physiotherapy for Functional Motor Disorder...

Assessment of the Impact of RNase in Patients With Severe Fatigue Related to Post-Acute Sequelae of SARS-CoV-2 Infection PASC: A Randomized Phase 2 Trial of RSLV-132 Andrews, James S; Boonyaratanakornkit, Jim B; Krusinska, Eva; Allen, Suzanne; Posada, James A BACKGROUND Severe acute respiratory...

A Comprehensive and Broad Approach to Resting-State Functional Connectivity in Adult Patients with Mild Traumatic Brain Injury Soroush Arabshahi; Sohae Chung; Alaleh Alivar; Prin X. Amorapanth; Steven R. Flanagan; Farng-Yang A. Foo; Andrew F. Laine; Yvonne W. Lui BACKGROUND AND PURPOSE Several...

Use of testosterone replacement therapy to treat long-COVID-related hypogonadism Alessandro Amodeo; Luca Persani; Marco Bonomi; Biagio Cangiano Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can impair pituitary–gonadal axis and a higher prevalence of hypogonadism in...

Graded exercise therapy compared to activity management for paediatric chronic fatigue syndrome/myalgic encephalomyelitis: pragmatic randomized controlled trial Gaunt, Daisy M.; Brigden, Amberly; Harris, Shaun R. S.; Hollingworth, William; Jago, Russell; Solomon-Moore, Emma; Beasant, Lucy...

Abstract Objective: This study assesses response to intravenous immunoglobulin (IVIG) in presumed autoimmune postural orthostatic tachycardia syndrome (POTS). Background: POTS may be associated with autoimmune disorders, serum autoantibodies, or recent infection. Uncontrolled case studies...

Transcranial direct current stimulation tDCS in the treatment of neuropsychiatric symptoms of long COVID Klírová, Monika; Adamová, Andrea; Biačková, Nina; Laskov, Olga; Renková, Veronika; Stuchlíková, Zuzana; Odnohová, Karolína; Novák, Tomáš The study aimed to assess the efficacy of...

Confirmation of COVID-19 infection status and reporting of Long COVID symptoms in a population-based birth cohort: No evidence of a nocebo effect Catherine IA Macleod-Hall; Marcus R Munafò; Maddy L Dyer Some patients with COVID-19 develop symptoms after the acute infection, known as ‘Long...

Retinal Microvasculature Image Analysis Using Optical Coherence Tomography Angiography in Patients with Post-COVID-19 Syndrome, 2023, Noor et al. Retinal Microvasculature Image Analysis Using Optical Coherence Tomography Angiography in Patients with Post-COVID-19 Syndrome Noor, Maha; McGrath...

Examination of autoantibodies to type I interferon in patients suffering from long COVID Kristoffer Skaalum Hansen; Sofie Eg Jørgensen; Morten Kelder Skouboe; Jane Agergaard; Berit Schiøttz-Christensen; Line Khalidan Vibholm; Martin Tolstrup; Lars Østergaard; Steffen Leth; Trine H. Mogensen...