Post-COVID microvascular dysfunction in hospitalized COVID-19 survivors is associated with acute disease severity and persistent cognitive complaints
Noa van der Knaap; Simona Klinkhammer; Alida A. Postma; Johanna M.A. Visser-Meily; Janneke Horn; Caroline M. van Heugten; Paulien H.M. Voorter...
Abstract
Essential elements of Myalgic Encephalomyelitis (ME) are muscle (weakness) and tenderness, cognitive deficits, neurological impairments, especially of cognitive, autonomic and sensory functions, but above all, post-exertional “malaise”: a prolonged increase of symptoms after a minor...
Fatigue is a major symptom in many diseases, often among the most common and severe ones and may last for an extremely long period. Chronic fatigue impacts quality of life, reduces the capacity to perform activities of daily living, and has socioeconomical consequences such as impairing return...
Abstract
Persistent symptoms after acute COVID-19 infection, termed post-COVID-19 fatigue, occur in 44–70% of patients. Characterizing fatigue in this population is vital to determine the etiology of post-COVID-19 fatigue symptoms and to assess the effectiveness of potential interventions...
Harrison, A. M., das Nair, R., & Moss-Morris, R. (2016). Operationalising cognitive fatigability in multiple sclerosis: A Gordian knot that can be cut? Multiple Sclerosis Journal, 23(13), 1682–1696. doi:10.1177/1352458516681862
sci-hub.se/10.1177/1352458516681862
Abstract
Background...
Darragh, M., Chang, J. W.-H., Booth, R. J., & Consedine, N. S. (2015). The placebo effect in inflammatory skin reactions. Journal of Psychosomatic Research, 78(5), 489–494. doi:10.1016/j.jpsychores.2015.01.011
ResearchGate link here
Scihub link here
This study found that a placebo cream...
The following list of studies and other papers could be helpful with regard to the claim that symptoms classified as 'fatigue' can't be measured objectively, or that potential objective measures are too unspecific.
In the field of MS research, some people looked for objective measures...
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