pdk4

  1. leokitten

    SARS-CoV-2 ORF7a drives mitochondrial dysfunction via PDK4 activation and complex I inhibition, 2026, Fernandez-Rodriguez et al

    Highlights • SARS-CoV-2 ORF7a drives glycolytic and mitochondrial rewiring • The accessory protein ORF7a induces PDK4 and restricts pyruvate oxidation • Mitochondrial complex I activity is selectively impaired by ORF7a • ORF7a disrupts respiratory supercomplex assembly and redox balance Summary...
    • leokitten
    • Thread
    • covid-19 glycolysis mitochondria pdk4 peroxiredoxin pyruvate pyruvate dehydrogenase kinase
    • Replies: 2
    • Forum: Long Covid research
  2. Dolphin

    Metabolic adaptation and fragility in healthy 3-D in vitro skeletal muscle tissues exposed to [CFS] and Long COVID-19 sera, 2025, Mughal+

    Preliminary abstract, see post #13 for final paper. ----------------- https://www.sciencedirect.com/science/article/abs/pii/S0960896624003353 571P Muscular metabolic plasticity in 3D in vitro models against systemic stress factors in ME/CFS and long COVID-19 Author links 1 Institute For...
    • Dolphin
    • Thread
    • calcium drp1 glycolysis mitochondria mitochondrial morphology muscle muscle fatigability oxygen use pdk4 serum something in the blood
    • Replies: 65
    • Forum: ME/CFS research
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