plasma cells

  1. SNT Gatchaman

    C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain, 2026, Crowley et al.

    C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain INTRODUCTION Synaptic elimination is a fundamental process that can engage microglia and the classical complement cascade, yet the mechanisms that specify which synapses are targeted by complement component 1q...
  2. Formerhuman

    Teclistamab for treatment-refractory autoimmune diseases: a multicentre case series, 2026, Fredrik N Albach et al.

    Teclistamab for treatment-refractory autoimmune diseases: a multicentre case series ABSTRACT Objectives This study aimed to evaluate the safety and efficacy of teclistamab, a T cell–redirecting bispecific antibody targeting B-cell maturation antigen, in a case series of severe autoimmune...
  3. Nightsong

    Exploring differences in protein cargo of extracellular vesicles from ME/CFS patient plasma compared to healthy controls, 2026, Rydland et al

    Abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease characterized by post-exertional malaise, fatigue and pain. Yet, its underlying biological mechanisms remain poorly understood. Extracellular vesicles (EVs) are nanoparticles carrying...
    • Nightsong
    • Thread
    • ambp bone marrow coagulation complement extracellular vesicles fibrinogen haemoglobin ighv itih3 liver me/cfs plasma cells
    • Replies: 9
    • Forum: ME/CFS research
  4. SNT Gatchaman

    Preprint Defective B cell tolerance in SLE lymph nodes underpins VH4-34 "clonal damnation" and PD-1+TOX+ autoreactive B cells expansion., 2026, Faliti et al.

    Defective B cell tolerance in SLE lymph nodes underpins VH4-34 "clonal damnation" and PD-1+TOX+ autoreactive B cells expansion. Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease driven by uncensored B and T cell autoreactivity. Understanding this pathogenic process has been...
    • SNT Gatchaman
    • Thread
    • autoimmunity b cell receptor b cells ebna ebna1 ebv germinal centres igg4 immune depletion lymph nodes plasma cells systemic lupus erythematosus
    • Replies: 2
    • Forum: Other health news and research
  5. R

    Teclistamab for ME/CFS

    It seems as though Dr. Habets has successfully treated an ME patient with low doses teclistamab. Much more cost effective than daratumumab apparently (< 1000€ per treatment course). This is the German maverick oncologist that's also treated ME patients successfully with daratumumab in the past...
  6. Mij

    Single-cell RNA-Seq reveals intracellular microbial diversity within immune cells during SARS-CoV-2 infection and recovery, 2023, Sunita Yadav et al

    Highlights 76 bacterial species of 15 genera across healthy, COVID-19-positive, and recovered individuals Higher abundance of opportunistic intracellular bacteria in recovered group Higher microbial abundance within antigen-presenting cells of COVID-19 patients Differential microbial abundance...
    • Mij
    • Thread
    • b cells covid dendritic cells innate immune response intracellular infection intracellular pathogen macrophages monocytes nk cells pbmc plasma cells platelets single-cell transcriptomics t cells
    • Replies: 6
    • Forum: Epidemics (including Covid-19, not Long Covid)
  7. J

    Patent: Method for the treatment of CFS using an inhibitory or cytotoxic agent against plasma cells, 2021, Fluge, Mella

    I've just come across a patent from Fluge and Mella which looks like it was updated/published in March 2021 entitled 'Method for the treatment of chronic fatigue syndrome using an inhibitory or cytotoxic agent against plasma cells'. The description of the patent is a long read...
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