prion-like domains

  1. Colin

    Review The structural line between prion and “prion-like”: Insights from prion protein and tau, 2024, Glynn et al

    Highlights Prion-like aggregates exit, are taken up, and propagate across cells and tissues. Tau fibril structures point to isoform-composition-based structural patterns. Prion strains share structural similarities despite host prion sequence variation. GSS harbors a distinct structure to...
  2. Colin

    Review Recombinant SARS-CoV-2 Spike Protein and Prion-Like Domains: Persistent Cross-Seeding of Amyloid-β and Tau ..., 2026, Cantanzaro et al

    Abstract Persistent SARS-CoV-2 spike protein after mRNA vaccination and after infection has been linked to a broad range of chronic pathology, yet the structural basis of that persistence is frequently described imprecisely. This analysis examines the sequence features that render spike...
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