prion

Highlights Prion-like aggregates exit, are taken up, and propagate across cells and tissues. Tau fibril structures point to isoform-composition-based structural patterns. Prion strains share structural similarities despite host prion sequence variation. GSS harbors a distinct structure to...

Abstract 'Prion' is a term used to describe a protein infectious particle responsible for several neurodegenerative diseases in mammals, e.g., Creutzfeldt-Jakob disease. The novelty is that it is protein based infectious agent not involving a nucleic acid genome as found in viruses and...

Amyloid-forming potential of Betacoronavirus including SARS-CoV-2 Hazem Haddad, Walid Al-Zyoud Abstract Prions are considered as sub-viral protein particles that have exceptional ability for multiple structural or functional conformational changes, leading to amyloid or prion forming or...

Rapidly evolving Creutzfeldt–Jakob disease in COVID-19: from early status epilepticus to fatal outcome Olivo, S., Furlanis, G., Buoite Stella, A. et al. We report the case of a 70-year-old man coming to our attention for new onset refractory status epilepticus (NORSE) in a rapidly evolving CJD...