pyruvate dehydrogenase kinase

  1. leokitten

    SARS-CoV-2 ORF7a drives mitochondrial dysfunction via PDK4 activation and complex I inhibition, 2026, Fernandez-Rodriguez et al

    Highlights • SARS-CoV-2 ORF7a drives glycolytic and mitochondrial rewiring • The accessory protein ORF7a induces PDK4 and restricts pyruvate oxidation • Mitochondrial complex I activity is selectively impaired by ORF7a • ORF7a disrupts respiratory supercomplex assembly and redox balance Summary...
    • leokitten
    • Thread
    • covid-19 glycolysis mitochondria pdk4 peroxiredoxin pyruvate pyruvate dehydrogenase kinase
    • Replies: 2
    • Forum: Long Covid research
  2. forestglip

    Hypothesis How I treat my patients with Myalgic Encephalomyelitis, Chronic Fatigue Syndrome (ME/CVS), fibromyalgia or “long COVID”, 2025, Comhaire

    How I treat my patients with Myalgic Encephalomyelitis, Chronic Fatigue Syndrome (ME/CVS), fibromyalgia or “long COVID” Frank Comhaire Abstract Common to Myalgic encephalomyelitis, chronic fatigue syndrome and so-called long Covid is the panoply of complaints, with Post Exertional Malaise...
    • forestglip
    • Thread
    • ldn long covid me/cfs meldonium pyruvate dehydrogenase complex pyruvate dehydrogenase kinase sodium dichloroacetate
    • Replies: 5
    • Forum: ME/CFS research
Back
Top Bottom