rora

  1. Chandelier

    Preprint Seven replicated genomic associations of myalgic encephalomyelitis/chronic fatigue syndrome: a biobank study, 2026, Slaughter, Ponting et al.

    Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating female-biased disease with neither diagnostic biomarker nor effective treatment nor well-understood aetiology. To investigate its biological basis, we used TarGene to perform a genome-wide association study in...
    • Chandelier
    • Thread
    • bicd1 clybl csmd1 decodeme genetics grin2a mecfs ponting rora uk biobank
    • Replies: 86
    • Forum: ME/CFS research
  2. SNT Gatchaman

    Molecular architecture of human dermal sleeping nociceptors, 2026, Körner et al.

    Molecular architecture of human dermal sleeping nociceptors Human dermal sleeping nociceptors display ongoing activity in neuropathic pain, affecting 10% of the population. Despite advances in rodents, a molecular marker for these mechano-insensitive C-fibers (CMis) in human skin remains...
  3. forestglip

    Preprint Cluster analysis of ME/CFS symptoms in DecodeME reveals two subgroups and a link to onset type, 2026, St-Jean et al

    Cluster analysis of ME/CFS symptoms in DecodeME reveals two subgroups and a link to onset type St-Jean, Christa; Dibble, Joshua James; Ponting, Chris P; Prigge, Regina Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating, often infection-triggered illness...
    • forestglip
    • Thread
    • decodeme me/cfs retinoic acid rora spp2 subtype trpm trpm8
    • Replies: 54
    • Forum: ME/CFS research
  4. E

    Transcriptional reprogramming primes CD8+ T cells toward exhaustion in Myalgic encephalomyelitis/chronic fatigue syndrome, 2024, Iu, Hanson et al

    Transcriptional reprogramming primes CD8+ T cells toward exhaustion in Myalgic encephalomyelitis/chronic fatigue syndrome Significance Myalgic encephalomyelitis/chronic fatigue syndrome (ME) is a serious disabling chronic illness that lacks FDA-approved therapies. Comprehensive...
    • EndME
    • Thread
    • cd8+ cornell university hanson rora t-cells
    • Replies: 41
    • Forum: ME/CFS research
  5. Andy

    Heterogenous circulating miRNA changes in ME/CFS converge on a unified cluster of target genes: A computational analysis, 2023, Kaczmarek

    Abstract Myalgic Encephalomyelitis / Chronic Fatigue Syndrome is a debilitating, multisystem disease of unknown mechanism, with a currently ongoing search for its endocrine mediators. Circulating microRNAs (miRNA) are a promising candidate for such a mediator and have been reported as...
  6. SNT Gatchaman

    Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment, 2024, Greene et al

    Preprint Blood-brain barrier disruption in Long COVID-associated cognitive impairment Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O'Keeffe, Lilia Zaporojan, Emma Connolly, Cliona Ni Cheallaigh, Niall Conlon, Colin Doherty, Matthew Campbell Vascular disruption has been...
    • SNT Gatchaman
    • Thread
    • blood brain barrier brain imaging coagulation csf dce-mri endothelial gfap icam-1 inflammation mri p-selectin pf4 platelets rora s100 scam-1 spike protein t cells tgf-beta tnf
    • Replies: 44
    • Forum: Long Covid research
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