Trazodone has often been prescribed of label at a low dose for insomnia. It's primary use however is an SSRI antidepressant.
Trazodone is the most effective insomnia treatment I've ever tried. It really helped my sleep for a couple months until I had to discontinue it a year and a half ago due...
Autoantibodies, Polymorphisms in the Serotonin Pathway, and Human Leukocyte Antigen Class II Alleles in Chronic Fatigue Syndrome
Oscar-Danilo Ortega-Hernandez, Mariaclara Cuccia, Sara Bozzini, Nicola Bassi, Samuel Moscavitch, Lina-Marcela Diaz-Gallo, Miri Blank, Nancy Agmon-Levin, Yehuda...
The germline coordinates mitokine signaling
Koning Shen; Jenni Durieux; Cesar G. Mena; Brant M. Webster; C. Kimberly Tsui; Hanlin Zhang; Larry Joe; Kristen M. Berendzen; Andrew Dillin
The ability of mitochondria to coordinate stress responses across tissues is critical for health. In C...
Beyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder
Chloe E. Page, C. Neill Epperson, Andrew M. Novick, Korrina A. Duffy, Scott M. Thompson
Abstract
The serotonin deficit hypothesis explanation for major depressive disorder (MDD) has...
CROI - Conference on Retroviruses and Opportunistic Infections
At this years CROI conference there were some presentations on Long-COVID (videos can be found at https://www.croiwebcasts.org/portal/ by using search terms such as "Long-Covid" or "post-acute"). There were also presentations of...
Clearance of gut mucosal SARS-CoV-2 antigens and post-acute COVID-19 after two years in patients with inflammatory bowel disease
Andreas Zollner; Robert Koch; Almina Jukic; Alexandra Pfister; Moritz Meyer; Nikolaus Wick; Georg Wick; Annika Rössler; Janine Kimpel; Timon E. Adolph; Herbert Tilg...
Long COVID-19 and Peripheral Serotonin: A Commentary and Reconsideration
George M Anderson; Edwin H Cook; Randy D Blakely; James S Sutcliffe; Jeremy Veenstra-VanderWeele
We believe there are serious problems with a recently published and highly publicized paper entitled “Serotonin reduction in...
Plasma Instead of Serum Avoids Critical Confounding of Clinical Metabolomics Studies by Platelets
Gerhard Hagn; Samuel M. Meier-Menches; Günter Plessl-Walder; Gaurav Mitra; Thomas Mohr; Karin Preindl; Andreas Schlatter; Doreen Schmidl; Christopher Gerner; Gerhard Garhöfer; Andrea Bileck...
Assessing the effect of selective serotonin reuptake inhibitors in the prevention of post-acute sequelae of COVID-19
Hythem Sidky; Kristen A. Hansen; Andrew T. Girvin; Nathan Hotaling; Sam G. Michael; Ken Gersing; David K. Sahner
BACKGROUND
Post-acute sequelae of COVID-19 (PASC) produce...
Treatment of 95 post-Covid patients with SSRIs
Rus, Carla P.; de Vries, Bert E. K.; de Vries, Ingmar E. J.; Nutma, Idelette; Kooij, J. J. Sandra
After Covid-19 infection, 12.5% develops post-Covid-syndrome (PCS). Symptoms indicate numerous affected organ systems. After a year, chronic fatigue...
Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID
Kaiming Wang; Mobin Khoramjoo; Karthik Srinivasan; Paul M.K. Gordon; Rupasri Mandal; Dana Jackson; Wendy Sligl; Maria B. Grant; Josef M. Penninger; Christoph H. Borchers; David S. Wishart...
https://onlinelibrary.wiley.com/doi/10.1111/all.15253
Letter, open access
Cork study
Serum was obtained from PASC patients (n = 20) at two time points (4–6 months following infection (T1) and 6–9 months following infection (T2)). All patients had been hospitalized for PCR-proven SARS-CoV-2...
Serotonin reduction in post-acute sequelae of viral infection
Highlights
Long COVID is associated with reduced circulating serotonin levels
Serotonin depletion is driven by viral RNA-induced type I interferons (IFNs)
IFNs reduce serotonin through diminished tryptophan uptake and...
Immunometabolic rewiring in long COVID patients with chronic headache
Suan-Sin Foo, Weiqiang Chen, Kyle L Jung, Tamiris Azamor, Un Yung Choi, Pengfei Zhang, Suzy AA Comhair, Serpil C Erzurum, Lara Jehi, Jae U Jung
Almost 20% of patients with COVID-19 experience long-term effects, known as...
Study finds first direct evidence of a link between low serotonin and depression
From the Guardian, science correspondent:
Link to the study:
BRAIN SEROTONIN RELEASE IS REDUCED IN PATIENTS WITH DEPRESSION: A [11C]Cimbi-36 PET STUDY WITH A D-AMPHETAMINE CHALLENGE.
Joanna Moncrieff, Ruth E. Cooper, Tom Stockmann, Simone Amendola, Michael P. Hengartner & Mark A. Horowitz
The serotonin hypothesis of depression is still influential. We aimed to synthesise and evaluate evidence on whether depression is associated with lowered serotonin concentration or...
Something I have now seen a number of times over the last few months is people who have just been diagnosed talking about how it has been confirmed with a 5HT test. It would seem the healthcare (NHS-based it seems, maybe all from similar or the same place?) involved states this to be some sort...
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