sphingolipids

https://www.medrxiv.org/content/10.1101/2025.04.13.25325733v1 Abstract Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating condition with unclear etiology and no FDA-approved treatment. Recent studies suggest a possible genetic contribution to its...

A research perspective on sphingolipid metabolism and myalgic encephalomyelitis/chronic fatigue syndrome Xiao, Junhua No abstract. Link | PDF (Neural Regeneration Research)

Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19 Ronaldo Lira-Junior; Anoop Ambikan; Axel Cederholm; Ssefanit Rezene; Flora Mikaeloff; Sara Svensson Akusjarvi; Ahmet Yalcinkaya; Xi Chen; Maike Sperk...

Integrative Multi-Omics Framework for Causal Gene Discovery in Long COVID Thuc Duy Le, Sindy Licette Pinero, Xiaomei Li, Lin Liu, Jiuyong Li, Sang Hong Lee, Marnie Winter, Thin Nguyen, Junpeng Zhang Background Long COVID, or Post–Acute Sequelae of COVID–19 (PASC), involves persistent...

Highlights •FM patients have higher anti-SGC IgG levels associated with pain intensity •FM patients have lower levels of phospholipid classes, sphingomyelin, and triglycerides •FM patients have higher levels of diglycerides •FM severe have higher levels of some lysophosphatidylcholines than FM...

Full Title: SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection, 2024, Alexsia Richards et al Abstract Although respiratory symptoms are the most prevalent disease manifestation of...

Proteomic and metabolomic profiling of plasma uncovers immune responses in patients with Long COVID-19 Yulin Wei, Hongyan Gu, Jun Ma, Xiaojuan Mao, Bing Wang, Weiyan Wu, Shimin Yu, Jinyuan Wang, Huan Zhao, yanbin he [Preprint] Abstract Long COVID is an often-debilitating condition with...

Comparative Metabolomics of Four Fatigue Disorders: Chronic Fatigue Syndrome (CFS/ME), Long COVID, Fibromyalgia (FM), and Major Depressive Disorder (MDD) Heather G Kuruvilla, Colleen Weaver, Joshua Jones, Hunter Tenpas [Poster presentation at Scholars Symposium 2024] Fatigue is a common...

A blood-based mRNA signature distinguishes people with Long COVID from recovered individuals Missailidis, Daniel; Ebrahimie, Esmaeil; Mohammadi-Dehcheshmeh, Manijeh; Allan, Claire; Sanislav, Oana; Fisher, Paul Robert; Gras, Stephanie; Annesley, Sarah Jane Long COVID is a debilitating condition...

Katherine Huang, Alex G. C. de Sá, Natalie Thomas, Robert D. Phair, Paul R. Gooley, David B. Ascher & Christopher W. Armstrong Abstract Background Diagnosing complex illnesses like Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is complicated due to the diverse symptomology and...

Abstract Myalgic Encephalomyelitis (ME; sometimes referred to as chronic fatigue syndrome) is a relatively common and female-biased disease of unknown pathogenesis that profoundly decreases patients' health-related quality-of-life. ME diagnosis is hindered by the absence of robustly-defined and...

Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder Lingampelly, Sai Sachin; Naviaux, Jane C.; Heuer, Luke S.; Monk, Jonathan M.; Li, Kefeng; Wang, Lin; Haapanen, Lori; Kelland, Chelsea A.; Van de Water, Judy; Naviaux, Robert K. Classical...

Anti-Nociceptive Effects of Sphingomyelinase and Methyl-Beta-Cyclodextrin in the Icilin-Induced Mouse Pain Model Horváth, Ádám; Steib, Anita; Nehr-Majoros, Andrea; Kántás, Boglárka; Király, Ágnes; Racskó, Márk; Tóth, Balázs István; Szánti-Pintér, Eszter; Kudová, Eva; Skoda-Földes, Rita; Helyes...

Reinforcing the Evidence of Mitochondrial Dysfunction in Long COVID Patients Using a Multiplatform Mass Spectrometry-Based Metabolomics Approach Sara Martínez; Oihane E. Albóniga; María Rosa López-Huertas; Ana Gradillas; Coral Barbas Despite the recent and increasing knowledge surrounding...

Plasma Instead of Serum Avoids Critical Confounding of Clinical Metabolomics Studies by Platelets Gerhard Hagn; Samuel M. Meier-Menches; Günter Plessl-Walder; Gaurav Mitra; Thomas Mohr; Karin Preindl; Andreas Schlatter; Doreen Schmidl; Christopher Gerner; Gerhard Garhöfer; Andrea Bileck...

Lipidomics signature in post-COVID patient sera and its influence on the prolonged inflammatory response Abstract Background: The ongoing issues with post-COVID conditions (PCC), where symptoms persist long after the initial infection, highlight the need for research into blood lipid changes...

The role of Sphingolipids in myelination and myelin stability and their involvement in childhood and adult demyelinating disorders Paola Giussani; Alessandro Prinetti; Cristina Tringali Multiple sclerosis (MS) represents the most common demyelinating disease affecting the central nervous system...

Sphingolipids and their metabolism in physiology and disease Hannun, Yusuf A.; Obeid, Lina M. Studies of bioactive lipids in general and sphingolipids in particular have intensified over the past several years, revealing an unprecedented and unanticipated complexity of the lipidome and its many...

Alterations to Sphingomyelin Metabolism Affect Hemostasis and Thrombosis Jue Wang; Shiva Keshava; Kaushik Das; Richard Kolesnick; Xian-Cheng Jiang; Usha R. Pendurthi; L. Vijaya Mohan Rao BACKGROUND: Our recent studies suggest that sphingomyelin levels in the plasma membrane influence TF (tissue...

Impact of sphingolipids on protein membrane trafficking Aguilera-Romero; Lucena; Sabido-Bozo; Muñiz Membrane trafficking is essential to maintain the spatiotemporal control of protein and lipid distribution within membrane systems of eukaryotic cells. To achieve their functional destination...